Перекисное окисление липидов при острой интоксикации летучими компонентами эпоксидных смол и его фармакологическая коррекция

Abstract

In the experiments on the white rat-males line Wistar found out that acute, dinamic, ingalating intoxication by the flying compounds of the epoxyde resine ED-20 (ER) increase the intensity of peroxide lipoid oxidation (PLO) in the animal liver. Showed, that the strongest anti-radical and anti-oxidazative activity in the process of poisoning by ER belong to quercetine. A bit less expressed influence on the process of PLO in liver showed lipine and clofibrate. Action of flavinate was more expressed on the phase of free-radical (FR) forming; was less expressed then for lipine and clofibrate and carried a biphased disposition with maximum decrease of FR in 6 and 72 hours after the intoxication by ER. Anti-oxidazative qualities of flavinate manifestated in early-; and of acetylcysteine - in earlier terms of experiment. When we used omeprasole the essential influence on the process of PLO in the poisoning animal liver hadn’t seen. In this work we discussed the mechanisms of anti-oxidazative activity of used medicines. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/1462