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Title | Mass spectrometry analysis of prospidine alkilation products |
Authors |
Obewu-Onwuka, L.
Grebenik, L.I. |
ORCID | |
Keywords | |
Type | Conference Papers |
Date of Issue | 2011 |
URI | http://essuir.sumdu.edu.ua/handle/123456789/15938 |
Publisher | Видавництво СумДУ |
License | |
Citation | Obewu-Onwuka, Lovina Mass spectrometry analysis of prospidine alkylation products [Текст] / L. Obewu-Onwuka, L.I. Grebenik // Актуальні питання теоретичної медицини. Актуальні питання клінічної медицини. Клінічні та патогенетичні аспекти мікроелементозів. Actual problems of fundamental and clinical medicine : матеріали науково-практичних конференцій студентів, молодих вчених, лікарів та викладачів, Суми, 21-22 квітня 2011 року / Відп. за вип. Л.Н. Приступа. - Суми : СумДУ, 2011. - Ч.2. - C. 91. |
Abstract |
Among the drugs currently being used in the clinical chemotherapy of cancer, an important place is occupied by derivatives of dispirotripiperaziniun such as prospidine. Prospidine has a unique mechanism of antitumor action which is not yet sufficiently clear. The main targets of the action of most antitumor drugs are DNA and RNA, it seemed necessary to study first of all the interaction of prospidine with the components of nucleic acids. Mass spectrometry methods provide a unique opportunity for molecular specific analyses of anticancer drug interaction with components of nucleic acids.
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