Serum cortisol contents in newborns with disturbance renal function due to asphyxia

Abstract

The objective. To study the dynamics of the cortisol level during the neonatal period in infants with violation kidney function after asphyxia. Materials and methods. 100 full-term infants with a gestational age 38-41 weeks and signs of kidney damage were examined: 50 children who had severe asphyxia and 50 children with moderate asphyxia. The comparison group consisted of 20 children without birth asphyxia. The cortisol level in serum was determined on 1-2, 7-8 and 25-30 days of life by ELISA. Results. Newborns with signs of kidney damage due to moderate asphyxia are characterized by significant increase in serum cortisol concentration at 1-2 days of life (p<0,001). Reduction to physiological levels observed only in the late neonatal period. Children with renal damage after severe asphyxia have the highest content of serum cortisol in the first two days of life - 505,28 ± 36,96 nmol/l. At the end of the neonatal period we observed suppression of cortisol production. The cortisol level in children with impaired renal function negatively correlated with low blood pH and base deficiency (BE). The high content of sodium in the serum in infants with impaired renal function caused by asphyxia in the first two days of life is an adaptive response due to elevated cortisol level. Conclusion. Investigation found that disturbance renal function after neonatal asphyxia accompanied with increase synthesis of cortisol in the early neonatal period. Depletion synthesis of cortisol in case of severe asphyxia at the end of the neonatal period may contribute disadaptation infants, predispose to metabolic disorders. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/33945