Micellar Structures of PAAm-b-PEO-b-PAAm Triblock Copolymers: Formation, Morphology, and Application as Drug Carries

Zheltonozhskaya, T.V.; Partsevskaya, S.V.; Klymchuk, D.O

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Title	Micellar Structures of PAAm-b-PEO-b-PAAm Triblock Copolymers: Formation, Morphology, and Application as Drug Carries
Authors	Zheltonozhskaya, T.V. Partsevskaya, S.V. Klymchuk, D.O
ORCID
Keywords	Triblock Copolymer Intramolecular Polycomplex Micellization Drug Encapsulation
Type	Conference Papers
Date of Issue	2012
URI	http://essuir.sumdu.edu.ua/handle/123456789/34795
Publisher	Sumy State University
License	Copyright not evaluated
Citation	Zheltonozhskaya, T.V. Micellar Structures of PAAm-b-PEO-b-PAAm Triblock Copolymers: Formation, Morphology, and Application as Drug Carries [Текст] / T.V. Zheltonozhskaya, S.V. Partsevskaya, D.O. Klymchuk // Nanomaterials: Applications & Properties (NAP-2012) : 2-nd International conference, Alushta, the Crimea, September 17-22, 2012 / Edited by: A. Pogrebnjak. - Sumy : Sumy State University, 2012. - V.1, No1. - 01PCN07
Abstract	The micellization of asymmetric PAAm-b-PEO-b-PAAm triblock copolymers (TBCs) with increasing length of chemically complementary polyacrylamide and poly(ethylene oxide) blocks was studied using static light scattering, photography, UV-Vis spectroscopy and TEM. The formation of “hairy-type” and “flower-like” micelles was established in dilute aqueous and aqueous/ethanol solutions. The “hairy” micelles contained a “core” comprised cooperatively interacting PEO and PAAm segments and “corona” formed by unbound units of longer PAAm blocks. Appearance of the “flower-like” micelles was conditioned by insolubility of PAAm blocks. Stability of the “flower-like” micelles was higher than that of the "hairy-type" ones. Significant encapsulation of a model drug prednisolon by TBC micelles was established. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/34795
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