Anionic Micelle-Forming Triblock Copolymers as Nanocontainers for Doxorubicin

Kunitskaya, L.R.; Stoika, R.S.; Shlyakhtina, Ye.A.; Zheltonozhskaya, T.B.; Permyakova, N.M.; Boiko, N.M

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Title	Anionic Micelle-Forming Triblock Copolymers as Nanocontainers for Doxorubicin
Authors	Kunitskaya, L.R. Stoika, R.S. Shlyakhtina, Ye.A. Zheltonozhskaya, T.B. Permyakova, N.M. Boiko, N.M
ORCID
Keywords	Amphiphilic Block Copolymers Drug Micellization Poly(Ethylene Oxide) Polyacrylamide
Type	Conference Papers
Date of Issue	2012
URI	http://essuir.sumdu.edu.ua/handle/123456789/34970
Publisher	Sumy State University
License	Copyright not evaluated
Citation	Anionic Micelle-Forming Triblock Copolymers as Nanocontainers for Doxorubicin / L. R. Kunitskaya, R. S. Stoika, Y. A. Shlyakhtina et al. // Nanomaterials: Applications & Properties (NAP-2012) : 2-nd International conference, Alushta, the Crimea, September 17-22, 2012 / Edited by: A. Pogrebnjak. - Sumy : Sumy State University, 2012. - V. 1, No2. - 02NNBM10
Abstract	The anionic derivative of asymmetric triblock copolymer containing biocompatible chemically complementary polyacrylamide and poly(ethylene oxide) (PAAm-b-PEO-b-PAAm) was obtained. The micellization of the initial (TBC) and modified (TBC-COOH) copolymer samples in aqueous solution were investigated. Practically the same values of the critical micellization concentration and the Gibbs free micellization energy for both TBCs were found. The anticancer effects of the doxorubicin (DOX)-loaded micelles of the initial and modified triblock copolymers were studied on the tumor cells of human T-leukemia of Jurkat line, transformed leukemia of L929 line and mouse lymphatic leukemia of L1210 line. The fact of high efficacy of DOX/TBC and DOX/TBC-COOH compositions in compare with pure DOX was determined and discussed. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/34970
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