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Title | Specific Interactions and Crystallization of Drug-Loaded Micelles in the System: Prednisolon/PAAm-b-PEO-b-PAAm Micellar Solutions |
Authors |
Zheltonozhskaya, T.B.
Partsevskaya, S.V. Klymchuk, D.O. Gorchev, V.F. |
ORCID | |
Keywords |
Triblock copolymer Intramolecular polycomplex Micelles Prednisolone Encapsulation |
Type | Conference Papers |
Date of Issue | 2013 |
URI | http://essuir.sumdu.edu.ua/handle/123456789/35235 |
Publisher | Sumy State University |
License | |
Citation | Specific Interactions and Crystallization of Drug-Loaded Micelles in the System: Prednisolon/PAAm-b-PEO-b-PAAm Micellar Solutions [Текст] / T.B. Zheltonozhskaya, S.V. Partsevskaya, D.O. Klymchuk, V.F. Gorchev // Nanomaterials: Applications & Properties (NAP-2013) : 3-rd International conference, Alushta, the Crimea, Ukraine, September 16-21, 2013 / Edited by: A. Pogrebnjak. - Sumy : Sumy State University, 2013. - V.2, No2. - 02PCN33 |
Abstract |
Encapsulaton of poorly soluble crystallizing drug prednisolone (PS) in micellar solutions of PAAm-b-
PEO-b-PAAm triblock copolymer (TBC) based on chemically complementary poly(ethylene oxide) and polyacrylamide
(MnPEO = 6 kDa, MnPAAm = 116 kDa) was studied by dynamic light scattering and transmission
electron microscopy. The equilibrium mechanism of the encapsulation process and the effect of specific aggregation
of PS-loaded micelles by their “coronas” that promoted the drug crystallization were established.
The question about the presence of TBC micelles inside crystalline space was discussed.
When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/35235 |
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