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Title Specific Interactions and Crystallization of Drug-Loaded Micelles in the System: Prednisolon/PAAm-b-PEO-b-PAAm Micellar Solutions
Authors Zheltonozhskaya, T.B.
Partsevskaya, S.V.
Klymchuk, D.O.
Gorchev, V.F.
ORCID
Keywords Triblock copolymer
Intramolecular polycomplex
Micelles
Prednisolone
Encapsulation
Type Conference Papers
Date of Issue 2013
URI http://essuir.sumdu.edu.ua/handle/123456789/35235
Publisher Sumy State University
License
Citation Specific Interactions and Crystallization of Drug-Loaded Micelles in the System: Prednisolon/PAAm-b-PEO-b-PAAm Micellar Solutions [Текст] / T.B. Zheltonozhskaya, S.V. Partsevskaya, D.O. Klymchuk, V.F. Gorchev // Nanomaterials: Applications & Properties (NAP-2013) : 3-rd International conference, Alushta, the Crimea, Ukraine, September 16-21, 2013 / Edited by: A. Pogrebnjak. - Sumy : Sumy State University, 2013. - V.2, No2. - 02PCN33
Abstract Encapsulaton of poorly soluble crystallizing drug prednisolone (PS) in micellar solutions of PAAm-b- PEO-b-PAAm triblock copolymer (TBC) based on chemically complementary poly(ethylene oxide) and polyacrylamide (MnPEO = 6 kDa, MnPAAm = 116 kDa) was studied by dynamic light scattering and transmission electron microscopy. The equilibrium mechanism of the encapsulation process and the effect of specific aggregation of PS-loaded micelles by their “coronas” that promoted the drug crystallization were established. The question about the presence of TBC micelles inside crystalline space was discussed. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/35235
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