Polyelectrolyte Nanocomplexes with pH-controlled Solubility

Gorshkova, M.Yr.; Volkova, I.V.; Grigorian, E.S.; Izumrudov, V.A.

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Title	Polyelectrolyte Nanocomplexes with pH-controlled Solubility
Authors	Gorshkova, M.Yr. Volkova, I.V. Grigorian, E.S. Izumrudov, V.A.
ORCID
Keywords	Nanoparticles Polyelectrolyte complexes Water-soluble chitosan Copolymer DIVEMA Drug delivery
Type	Conference Papers
Date of Issue	2013
URI	http://essuir.sumdu.edu.ua/handle/123456789/35468
Publisher	Sumy State University
License	Copyright not evaluated
Citation	Polyelectrolyte Nanocomplexes with pH-controlled Solubility [Текст] / M.Y. Gorshkova, I.V. Volkova, E.S. Grigorian, V.A. Izumrudov // Nanomaterials: Applications & Properties (NAP-2013) : 3-nd International conference, Alushta, the Crimea, September 16-21, 2013 / Edited by: A. Pogrebnjak. - Sumy : Sumy State University, 2013. - V.2, No4. - 04NABM19
Abstract	The prepared polyelectrolyte complexes of anionic copolymer of divinyl ester and maleic anhydride and cationic water soluble chitosan proved to be able to undergo reversible phase transition, in particular at physiological pH and ionic strength. Formation of either soluble or insoluble complexes occurred depending on pH value, charge ratio and degree of polymerization of the polymers. The stability of positively or negatively charged complexes against destruction action of the added salt drastically increased in acidic media presumably owing to H-bonds formation. According to light-scattering data, the size of the soluble complexes varied from 100 to 300 nm and remained virtually unchanged under storage after lyophilizing drying and resuspending in the same medium. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/35468
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