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Title | Investigation of the MGP promoter and exon 4 polymorphisms in patients with ischemic stroke in the Ukrainian population |
Authors |
Obukhova, Olha Anatoliivna
Harbuzova, Viktoriia Yuriivna Ataman, Oleksandr Vasylovych Ataman, Yurii Oleksandrovych Matlaj, O.I. |
ORCID |
http://orcid.org/0000-0002-2104-8412 http://orcid.org/0000-0001-7183-6997 http://orcid.org/0000-0002-1941-740X http://orcid.org/0000-0002-6398-1016 |
Keywords |
матриксний Gla-протеїн матриксный Gla-протеин Matrix Gla protein поліморфізм полиморфизм single nucleotide polymorphism ішемічний інсульт ишемический инсульт ischemic stroke кальцифікація судин кальцификация сосудов arterial calcification українська популяція украинская популяция ukrainian population |
Type | Article |
Date of Issue | 2012 |
URI | http://essuir.sumdu.edu.ua/handle/123456789/37742 |
Publisher | Haliç University, Printed in Turkey |
License | |
Citation | Investigation of the MGP promoter and exon 4 polymorphisms in patients with ischemic stroke in the Ukrainian population [Текст] / A.V. Ataman, V.Yu. Garbuzova, Yu.A. Ataman et al. // Journal of Cell and Molecular Biology. – 2012. – Vol.10, №1. – С. 19-26. |
Abstract |
Matrix γ-carboxyglutamic acid protein (MGP) is a vitamin K-dependent protein playing a pivotal role in
preventing arterial calcification. In the present study, we aimed to investigate the relation between three
single nucleotide polymorphisms of MGP gene and ischemic stroke (IS) in the Ukrainian population. 170 IS
patients and 124 healthy controls were recruited to the study. MGP SNPs were examined by PCR-RFLP
methodology. The distribution of homozygous carriers of the major allelic variant, and heterozygous and
homozygous minor allele variants of the T-138C MGP promoter polymorphism (rs1800802) in patients with
IS was 61.2%, 31.2% and 7.6%, respectively. The corresponding distributions of the variants in the control
group were 59.7%, 35.6%, 4.8%. With regard to the G-7A promoter polymorphism (rs1800801), the
respective distributions were 35.9%, 48.8% and 15.3%, compared to 43.5%, 50% and 6.5% in the control
group. Finally, the respective distributions according to the Thr83Ala exon 4 polymorphism (rs4236) were
39.4%, 48.8% and 11.8%, compared to 34.7%, 53.2% and 12.1% in the control group. Using logistic
regression analysis, it was estimated that A/A genotype (G-7A polymorphism) was significantly (P=0.016)
associated with IS (OR=2.943; 95% CI: 1.218–7.109) in the Ukrainian population. A-allele homozygotes of
female sex had a risk of IS more than 7 times higher compared with carriers of G/G genotype. |
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