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Title | S100, bcl2 and myeloperoxid protein expirations during periodontal inflammation |
Authors |
Kuzenko, Yevhen Viktorovych
Romaniuk, Anatolii Mykolaiovych Politun, A. Karpenko, Liudmyla Ivanivna |
ORCID |
http://orcid.org/0000-0003-3985-8912 http://orcid.org/0000-0003-2560-1382 http://orcid.org/0000-0002-5274-7021 |
Keywords |
S100 bcl2 MPO |
Type | Article |
Date of Issue | 2015 |
URI | http://essuir.sumdu.edu.ua/handle/123456789/41947 |
Publisher | BMC Oral Health |
License | |
Citation | Kuzenko, Y. S100, bcl2 and myeloperoxid protein expirations during periodontal inflammation [Text] / Y.Kuzenko, А. Romanyuk, A. Politun, L. Karpenko // BMC Oral Health. – 2015. - vol.15:93 - Р.1-6. |
Abstract |
Background:Periodontal inflammation is characterized by injuries in collagen, epithelial, bone tissues. The hypotheses
to be tested were relationship between the s100, bcl2 and myeloperoxidase in gingival tissues (MPO does affect the
level of s100, bcl2). The object of this study was to investigate of s100 expression, bcl2 expression and myeloperoxidase
expression in periodontal inflammation.
Methods:27 patients (giant-cell epulis) and 30 patients (acute and chronic inflammations) were included in the
study for s100 expression, bcl2 expression and myeloperoxidase expression by immunohistochemistry and
hematoxylin - eosin.
Results:Giant-cells in epulis positivity for myeloperoxidase has been observed in 100 % However, only 75.31 % of
giant-cells were positive for bcl2 expression. Acute 98.2 %, and chronic 89.28 % inflammation was a significant positive
for myeloperoxidase. The immunohistochemical findings of s100, bcl 2 and myeloperoxidase in epithelial layers have
showed the result of 100 %, 82,2 %, 100 % positive cells in acute and 100 %, 78.25 %, 100 % in chronic process of
inflammation respectively.
Conclusion:The results indicate that the pathogenesis of periodontal inflammation might involve inhibition of cell
death, through the overexpression of bcl-2, due to identifying factors myeloperoxidase (result in the DNA damage by
the product of catalysis). The highest levels of s100 activity have been found at sites with chronic inflammation. |
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File | Size | Format | Downloads |
---|---|---|---|
S100.pdf | 2.39 MB | Adobe PDF | -1534587523 |
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