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Title | Pathogenetic mechanisms of heavy metals effect on proapoptotic and proliferative potential of breast cancer |
Authors |
Romaniuk, Anatolii Mykolaiovych
Lyndin, Mykola Serhiiovych Moskalenko, Roman Andriiovych Kuzenko, Yevhen Viktorovych Hladchenko, Oksana Robertivna Gladchenko, Oksana Robertivna Lyndina, Yuliia Mykolaivna |
ORCID |
http://orcid.org/0000-0003-2560-1382 http://orcid.org/0000-0003-4385-3903 http://orcid.org/0000-0002-2342-0337 http://orcid.org/0000-0003-3985-8912 http://orcid.org/0000-0002-0788-764X http://orcid.org/0000-0002-2132-0965 |
Keywords |
рак молочної залози рак молочной железы breast cancer важких металів тяжелых металлов heavy metal фрагментація ДНК фрагментация ДНК DNA fragmentation проліферація пролиферация proliferation апоптоз apoptosis |
Type | Article |
Date of Issue | 2015 |
URI | http://essuir.sumdu.edu.ua/handle/123456789/42357 |
Publisher | Akadémiai Kiadó, Budapest |
License | |
Citation | Pathogenetic mechanisms of heavy metals effect on proapoptotic and proliferative potential of breast cancer / A. Romaniuk, M. Lyndin, R. Moskalenko [et al.] // Interv Med Appl Sci. - 2015. - 7(2). - P. 63–68. |
Abstract |
aterials and Methods:Chemical composition was studied with the help of the scanning electron microscope with energy-dispersion
spectrometer. Immunohistochemical reaction showed the p53 and Ki-67 receptors expression. The study of DNA fragmentation was performed
in agarose gel. Results:There was an interrelation between the accumulations of the trace elements with the degree of cancer malignancy. There
were 85% of cases with positive reaction to Ki-67 and 40% cases with positive reaction to p53. We found a moderate correlation between the
accumulation of microelements in the breast cancer tissue and the level of proliferative activity. We noted the combination of the increase of DNA
fragmentation with the expression of p53 and Ki-67 receptors. Conclusions:The trace elements can cause the initiation and the progression of the
tumorous growth, which is expressed in the increased proliferation of tumor cells. This leads to the destabilization of the genetic material which
can be expressed in the synthesis of mutant p53 protein. Finally, it leads to the block of apoptosis and regulatory effects of cells. This can cause the
tumor progression and the destabilization of the genome, which is reflected in the increased DNA fragmentation. |
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Breast_cancer_Romaniuk.pdf | 287.2 kB | Adobe PDF | -326788852 |
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