Обгрунтування синбіотиків у медичній практиці

Abstract

Стаття присвячена патогенетичному обгрунтуванню лікування пребіотиками та пробіотиками як складовими компонентами синбіотика «Лактен» у хворих із порушенням мікробіоти кишківника. У цьому огляді визначені переваги комбінації пребіотиків із пробіотиками порівняно з монотерапією.

Introduction. Based on modern concepts, intestine dysbiosis (microecological disorders of the gastrointestinal tract (GIT)) is regarded as clinical and laboratory syndrome that occurs in a number of diseases and is characterized by a change of qualitative and/or quantitative composition of the flora of a particular habitat and translocation of its representatives in their unusual habitats, metabolic and immune disorders, accompanied in some patients by clinical symptoms. Colon microbiota has a distinct individual character and differs both on species, and on strain levels. Main microflora of the colon includes anaerobic bacteria genus Bacteroides (Gram-negative bacteria belonging to about 20 families) and Firmicutes (Gram-positive bacteria belonging to more than 200 families). Aerobic bacterias are E. coli, lactobacilli, enterococci, etc., relating to the accompanying microflora. Microbiota violation causes many diseases, the list of which is growing. This list includes necrotizing enterocolitis in children, irritable bowel syndrome (IBS), antibiotic-associated diarrhea (AAD), inflammatory bowel disease (IBD), Crohn's disease (CD), chronic constipation, liver diseases, allergies, obesity, diabetes mellitus, metabolic syndrome, and others. The greatest risk of adverse effects of antibiotics is proved for penicillin group (5–10 %), the combination of amoxicillin and clavulanic acid (10–25 %), third-generation cephalosporins and clindamycin (15–20 %). One of the best combinations of pre- and probiotics, in our opinion, is a synbiotic "Lakten." It has the features of both the quantitative and qualitative levels. It consists of inulin, maltodextrin, magnesium stearate and ascorbic acid. Probiotic part of the "Lakten" are 8,000,000,000 Lactobacilli. Each of these components has a specific effect on intestinal microbiota and the entire body. Purpose. Considering the quality of raw materials, availability of effective prebiotics, high dose of Lactobacillus, synbiotic compliance (1 capsule per day), possibility of the use from the first day of antibiotic therapy, "Lakten" can be recommended for use in patients with intestine microbiota violations and requires further deep study of its properties.

Статья посвящена патогенетическому обоснованию лечения пребиотиками и пробиотиками как составными компонентами синбиотика «Лактен» у больных с нарушением микробиоты кишечника. В этом обзоре определены преимущества комбинации пребиотиков с пробиотиками по сравнению с монотерапией.