Osteopontin overexpression in papillary thyroid carcinoma with mineralization

Moskalenko, Roman Andriiovych; Romaniuk, Anatolii Mykolaiovych; Rieznik, Andrii Vasylovych; Lyndin, Mykola Serhiiovych; Sauliak, Serhii Volodymyrovych

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Title	Osteopontin overexpression in papillary thyroid carcinoma with mineralization
Authors	Moskalenko, Roman Andriiovych Romaniuk, Anatolii Mykolaiovych Rieznik, Andrii Vasylovych Lyndin, Mykola Serhiiovych Sauliak, Serhii Volodymyrovych
ORCID	http://orcid.org/0000-0002-2342-0337 http://orcid.org/0000-0003-2560-1382 http://orcid.org/0000-0003-4385-3903
Keywords	папілярний рак щитоподібної залози папиллярный рак щитовидной железы papillary thyroid carcinoma біомінералізація биоминерализация biomineralization остеопонтин остеопонтин odteopontin
Type	Conference Papers
Date of Issue	2016
URI	http://essuir.sumdu.edu.ua/handle/123456789/46494
Publisher	Springer
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Citation	Moskalenko, R. Osteopontin overexpression in papillary thyroid carcinoma with biomineralization / R. Moskalenko, A. Romaniuk, A. Rieznik [et al.] // Virchows Arch. – 2016. – Vol. 469, Suppl. 1. – S.74.
Abstract	Objective: Pathological mineralization (ectopic calcification) is an often finding in papillary thyroid carcinoma (PTC). The concept of pathological mineralization in papillary thyroid carcinoma included psammoma’s bodies, bone formation, stromal and vascular calcification. Osteopontin (OPN) is a glyco-phosphoprotein that is expressed and secreted by numerous human cancers. Osteopontin is upregulated at sites of pathologic, ectopic calcification—presumably at least in part to inhibit debilitating mineralization in these soft tissues. We investigated the expression of OPN and her correlation with pathological mineralization in PTC.
Appears in Collections:	Наукові видання (НН МІ)