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Title | Analysis of association Lys198Asn polymorphism of EDN1 gene with risk factors of ischemic atherothrombotic stroke in the Ukrainian population |
Authors |
Oleshko, Tetiana Bohdanivna
![]() Svyrydenko, Diana Yuriivna Yurchenko, Viktoriia Serhiivna Obukhova, Olha Anatoliivna ![]() Harbuzova, Viktoriia Yuriivna ![]() |
ORCID |
http://orcid.org/0000-0002-5909-5812 http://orcid.org/0000-0002-2104-8412 http://orcid.org/0000-0001-7183-6997 |
Keywords |
інсульти инсульты strokes |
Type | Conference Papers |
Date of Issue | 2016 |
URI | http://essuir.sumdu.edu.ua/handle/123456789/48362 |
Publisher | |
License | Copyright not evaluated |
Citation | Analysis of association Lys198Asn polymorphism of EDN1 gene with risk factors of ischemic atherothrombotic stroke in the Ukrainian population / T.B. Oleshko, D.Y. Svyrydenko, V.S. Yurchenko [et al.] // IV Eurasian congress of cardiologists. Yerevan, Armenia, 10-11 October 2016. – P. 46. |
Abstract |
One of the most important medical and social problems are
acute cerebrovascular disorders, among which the most part
is ischemic stroke. Known that in the development of stroke
leading role belongs to endothelial dysfunction (ED), the main
manifestation of which is the metabolic changes of the vascular
wall, the release of a significant amount endothelin-1 (EDN1)
and the development of vasoconstriction. Therefore, one of the
candidate genes, polymorphisms that can be associated with
a predisposition to the development of ED and consequently
contribute to stroke, is EDN1 gene. In order to improve the
prevention of stroke, we decided carry out a study among healthy
persons and identify possible susceptibility. The aim of our study
was to analyze the association Lys198Asn polymorphism of EDN1
gene with ischemic atherothrombotic stroke (IAS) risk factors in
the Ukrainian population. |
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Наукові видання (НН МІ) |
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