Analysis of association Lys198Asn polymorphism of EDN1 gene with risk factors of ischemic atherothrombotic stroke in the Ukrainian population

Oleshko, Tetiana Bohdanivna; Svyrydenko, Diana Yuriivna; Yurchenko, Viktoriia Serhiivna; Obukhova, Olha Anatoliivna; Harbuzova, Viktoriia Yuriivna

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Title	Analysis of association Lys198Asn polymorphism of EDN1 gene with risk factors of ischemic atherothrombotic stroke in the Ukrainian population
Authors	Oleshko, Tetiana Bohdanivna Svyrydenko, Diana Yuriivna Yurchenko, Viktoriia Serhiivna Obukhova, Olha Anatoliivna Harbuzova, Viktoriia Yuriivna
ORCID	http://orcid.org/0000-0002-5909-5812 http://orcid.org/0000-0002-2104-8412 http://orcid.org/0000-0001-7183-6997
Keywords	інсульти инсульты strokes
Type	Conference Papers
Date of Issue	2016
URI	http://essuir.sumdu.edu.ua/handle/123456789/48362
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Citation	Analysis of association Lys198Asn polymorphism of EDN1 gene with risk factors of ischemic atherothrombotic stroke in the Ukrainian population / T.B. Oleshko, D.Y. Svyrydenko, V.S. Yurchenko [et al.] // IV Eurasian congress of cardiologists. Yerevan, Armenia, 10-11 October 2016. – P. 46.
Abstract	One of the most important medical and social problems are acute cerebrovascular disorders, among which the most part is ischemic stroke. Known that in the development of stroke leading role belongs to endothelial dysfunction (ED), the main manifestation of which is the metabolic changes of the vascular wall, the release of a significant amount endothelin-1 (EDN1) and the development of vasoconstriction. Therefore, one of the candidate genes, polymorphisms that can be associated with a predisposition to the development of ED and consequently contribute to stroke, is EDN1 gene. In order to improve the prevention of stroke, we decided carry out a study among healthy persons and identify possible susceptibility. The aim of our study was to analyze the association Lys198Asn polymorphism of EDN1 gene with ischemic atherothrombotic stroke (IAS) risk factors in the Ukrainian population.
Appears in Collections:	Наукові видання (НН МІ)