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Title Immunohistochemical characteristics of aortic valve in the case of atherocalcinosis
Authors Romaniuk, Anatolii Mykolaiovych  
Moskalenko, Roman Andriiovych  
Zakorko, Inna-Marharyta Serhiivna
Lyndin, Mykola Serhiiovych  
Piddubnyi, Artem Mykhailovych  
Lyndina, Yuliia Mykolaivna  
Romaniuk, Sofiia Anatoliivna
Yashchishyn, Ihor Oleksandrovych  
ORCID http://orcid.org/0000-0003-2560-1382
http://orcid.org/0000-0002-2342-0337
http://orcid.org/0000-0003-4385-3903
http://orcid.org/0000-0002-6508-0131
http://orcid.org/0000-0002-2132-0965
http://orcid.org/0000-0002-1691-9025
Keywords аортальний клапан
аортальный клапан
aortic valve
біомінералізація
биоминерализация
biomineralization
атерокальциноз
atherocalcinosis
Type Conference Papers
Date of Issue 2017
URI http://essuir.sumdu.edu.ua/handle/123456789/65048
Publisher Springer
License
Citation Immunohistochemical characteristics of aortic valve in the case of atherocalcinosis / A. Romaniuk, R. Moskalenko, I.-M. Zakorko [et al.] // Virchows Arch. - 2017. - Vol. 471, Suppl. 1. – S. 188.
Abstract Objective: According to the results of the Euro-Heart Survey on Vascular Heart Disease the most common pathology is nonrheumatic aortic steno­sis, it is also called as calcific aortic valve stenosis (CAVS), as in its pathogenesis the process of biomineralization of valve cusps and ring plays the main role Method: 30 samples of mineralized aortic valves (I group) and 10 sam­ples of aortic valve without evidence of biomineralization (II group - control) were studied. Immunohistochemical study of expression of col­lagen I, CD68, MPO, S100A9), caspase3 andosteopontin was conducted in AV tissue of both groups. Results: In CAV tissues the fibrillar component (collagen I) growths was found, but the quantitative compositions of circulating inflammatory cells (CD68+) are not significantly different from the control group. CAVs contain much more MPO+ -cells (p< 0.001) in comparison to the group of AV without biomineralization. Our data show a significant increase of the S100A9 and OPN expression in the mineralized tissue of AVs (p < 0.01). Also a higher expression level of Casp3 and MPO was found in CAVs (p< 0.05). Conclusion: High Casp 3 expression confirms the increased level o f cell elimination in the CAVs tissue, which is obviously connected with the impact of high local concentrations ofS100A9. These facts can contribute to the development of pathological biomineralization o f AV. Since osteopontin inhibits the hydroxyapatite formation by binding to the surface of the crystals, its hyperproduction is a counteracting factor against biomin­eralization in AV tissue.
Appears in Collections: Наукові видання (НН МІ)

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