Body Mass Index in Patients with Bronchial Asthma with Regard to Gln27Glu Polymorphism β2-Adrenergic Receptor Gene

Prystupa, Liudmyla Nykodymivna; Bondarkova, Anna Mykolaivna; Murenets, N.; Kmyta, Vladyslava Volodymyrivna; Kuchma, N.G.; Psarova, Valentyna Hryhorivna

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Title	Body Mass Index in Patients with Bronchial Asthma with Regard to Gln27Glu Polymorphism β2-Adrenergic Receptor Gene
Authors	Prystupa, Liudmyla Nykodymivna Bondarkova, Anna Mykolaivna Murenets, N. Kmyta, Vladyslava Volodymyrivna Kuchma, N.G. Psarova, Valentyna Hryhorivna
ORCID	http://orcid.org/0000-0002-6454-9831 http://orcid.org/0000-0002-6748-9774 http://orcid.org/0000-0002-9563-5425 http://orcid.org/0000-0001-6890-272X
Keywords	бронхіальна астма бронхиальная астма bronchial asthma ожиріння ожирение obesity β2-адренорецептор β2-adrenoceptor поліморфізм Gln27Glu Gln27Glu полиморфизм Gln27Glu polymorphism
Type	Article
Date of Issue	2017
URI	http://essuir.sumdu.edu.ua/handle/123456789/74859
Publisher	India
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Citation	Body mass index in patients with bronchial asthma with regard to Gln27Glu polymorphism β2-adrenergis receptor gene / L.N. Prystupa, A.N. Bondarkova, N.A, Murenets [et al.] // Research Journal of Pharmaceutical, Biological and Chemical Sciences. – 2017. – № 8 (3). – Р. 933-938.
Abstract	Bronchial asthma (BA) and obesity due to their high prevalence and medical and social significance belong to global problems of healthcare. Obesity effect on asthma development includes the following mechanisms: impact on respiratory function, inflammation and common genetic factors. The aim of our research was to study the association between BMI and Gln27Glu polymorphism in the ADRB2 gene in BA patients. Patients with bronchial asthma were divided into 3 groups depending on their BMI: Group I – 110 patients with normal body mass; group II – 26 overweight patients, group III – 59 obese patients. Gln27Glu polymorphism in the ADRB2 gene was detected using polymerase chain reaction. Statistical analysis was performed using SPSS–21 program. P-value <0.05 was considered significant. Obtained results showed that obesity occurred more often in Glu27Glu genotype carriers, while normal body mass was more characteristic of Gln27Gln genotype carriers (р = 0.001). Distribution of BMI with regard to Gln27Glu polymorphism in the ADRB2 gene in BA patients did not depend on gender (р=0.1). Thus, BA patients with Glu27Glu genotype of the ADRB2 gene had obesity significantly more often.
Appears in Collections:	Наукові видання (НН МІ)