Serous Adenocarcinoma of Fallopian Tubes: Histological and Immunohistochemical Aspects

Hyriavenko, Nataliia Ivanivna; Lyndin, Mykola Serhiiovych; Sikora, Kateryna Oleksiivna; Piddubnyi, Artem Mykhailovych; Karpenko, Liudmyla Ivanivna; Гирявенко, Дмитрій Романович; Гирявенко, Дмитрий Романович; Hyriavenko, D.R.; Diachenko, Olena Olehivna; Sikora, Vladyslav Volodymyrovych; Romaniuk, Anatolii Mykolaiovych

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Title	Serous Adenocarcinoma of Fallopian Tubes: Histological and Immunohistochemical Aspects
Authors	Hyriavenko, Nataliia Ivanivna Lyndin, Mykola Serhiiovych Sikora, Kateryna Oleksiivna Piddubnyi, Artem Mykhailovych Karpenko, Liudmyla Ivanivna Гирявенко, Дмитрій Романович Гирявенко, Дмитрий Романович Hyriavenko, D.R. Diachenko, Olena Olehivna Sikora, Vladyslav Volodymyrovych Romaniuk, Anatolii Mykolaiovych
ORCID	http://orcid.org/0000-0002-9805-014X http://orcid.org/0000-0003-4385-3903 http://orcid.org/0000-0002-9814-6512 http://orcid.org/0000-0002-6508-0131 http://orcid.org/0000-0002-5274-7021 http://orcid.org/0000-0002-4147-6879 http://orcid.org/0000-0003-2560-1382
Keywords	серозна карцинома серозная карцинома serous carcinoma пухлина опухоль neoplasm фалопієві труби фаллопиевы трубы fallopian tubes рецептори до естрогену рецепторы к эстрогену estrogen receptors рецептори до прогестерону рецепторы к прогестерону progesteron receptors Ki-67 HER2/new p53 Bcl-2 судинний фактор росту сосудистый фактор роста vascular endothelial growth factor
Type	Article
Date of Issue	2019
URI	http://essuir.sumdu.edu.ua/handle/123456789/74907
Publisher	The Korean Society of Pathologists;The Korean Society for Cytopathology
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Citation	Serous Adenocarcinoma of Fallopian Tubes: Histological and Immunohistochemical Aspects / N. Hyriavenko, М. Lуndіn, K. Sikora [et al.] // Journal of Pathology and Translational Medicine. – 2019. – Vol. 53(4). – P. 236-243. – https://doi.org/10.4132/jptm.2019.03.21.
Abstract	Background: Although primary cancer of the fallopian tubes is a relatively rare type of tumor in female reproductive organs, its mortality is quite high. It is important to identify molecular and biological markers of this malignancy that determine its specific phenotype. Methods: The study was carried out on samples received from 71 female patients with primary cancer of the fallopian tubes. The main molecular and biological properties, including hormone status (estrogen receptor [ER], progesterone receptor [PR]), human epidermal growth factor receptor (HER2)/neu expression, proliferative potential (Ki-67), apoptosis (p53, Bcl-2), and pro-angiogenic (vascular endothelial growth factor) quality of serous tumors were studied in comparison with clinical and morphological characteristics. Results: ER and PR expression is accompanied by low grade neoplasia, early clinical disease stage, and absence of lymphogenic metastasis (p < .001). HER2/neu expression is not typical for primary cancer of the fallopian tubes. Ki-67 expression is characterized by an inverse correlation with ER and PR (p < .05) and is associated with lymphogenic metastasis (p < .01). p53+ status correlates with high grade malignancy, tumor progression, metastasis, negative ER/PR (p < .001), and negative Bcl-2 status (p < .05). Positive Bcl-2 status is positively correlated with ER and PR expression and low grade malignancy. Conclusions: Complex morphologic (histological and immunohistochemical) study of postoperative material allows estimation of the degree of malignancy and tumor spread to enable appropriate treatment for each case.
Appears in Collections:	Наукові видання (НН МІ)