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Title | The features of morphological changes in the urinary bladder under combined effect of heavy metal salts |
Authors |
Romaniuk, Anatolii Mykolaiovych
Sikora, Vladyslav Volodymyrovych Lyndin, Mykola Serhiiovych Smiianov, Vladyslav Anatoliiovych Sikora, Volodymyr Vitaliiovych Lyndina, Yuliia Mykolaivna Piddubnyi, Artem Mykhailovych Hyriavenko, Nataliia Ivanivna Korobchanska, Anna Borysivna |
ORCID |
http://orcid.org/0000-0003-2560-1382 http://orcid.org/0000-0002-4147-6879 http://orcid.org/0000-0003-4385-3903 http://orcid.org/0000-0001-8164-9706 http://orcid.org/0000-0003-4021-2334 http://orcid.org/0000-0002-2132-0965 http://orcid.org/0000-0002-6508-0131 http://orcid.org/0000-0002-9805-014X |
Keywords |
солі важких металів соли тяжелых металлов heavy metal salts сечовий міхур мочевой пузырь urinary bladder гістологічні дослідження гистологические исследования histological studies імуногістохімічні дослідження иммуногистохимические исследования immunohistochemical studies Ki-67 Hps90α зовнішнє середовище окружающая среда environment |
Type | Article |
Date of Issue | 2017 |
URI | http://essuir.sumdu.edu.ua/handle/123456789/74944 |
Publisher | Interventional Medicine & Applied Science |
License | |
Citation | The features of morphological changes in the urinary bladder under combined effect of heavy metal salts / A. Romaniuk, V. Sikora, M. Lyndin et al. // Interventional Medicine & Applied Science. - 2017. - № 9(2). - P. 1-7. DOI:10.1556/1646.9.2017.2.09. |
Abstract |
Abstract: Purpose: This study is aimed to the investigation of the features of morphological changes in the urinary bladder of mature rats. Results: Received results shown that the experimental group of rats that had the intake of heavy metal salts (HMS) mixture during 30 and 90 days were observed histological and immunohistochemical changes in all structures of the urinary bladder. Depending on the period of influence of heavy metal ions on the wall of the organ, the pathological changes developed in cellular layers of the wall can lead to degenerative and later to atrophic and sclerotic changes.
Conclusions: This study demonstrates that high concentrations ofHMS can significantly influence the body. The histological and immunohistochemical studies showed that the influence of the HMS combination leads to deep morphological changes in all structures of the urinary bladder. These changes depend on the period of intake of HMS. Analysis of the obtained results demonstrates the dependence of expression of morphological changes in the urinary bladder on the experiment duration. The final result of these changes may lead to the disorders of bladder’s functions. |
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Romaniuk_Нeavy_metal.pdf | 1.12 MB | Adobe PDF | 71766146 |
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