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Title | Peculiarities of megakaryocytes and platelets variation in the microelementosis condition |
Authors |
Lyndina, Yuliia Mykolaivna
Sikora, Vladyslav Volodymyrovych Hyriavenko, Nataliia Ivanivna Lyndin, Mykola Serhiiovych Karpenko, Liudmyla Ivanivna Romaniuk, Anatolii Mykolaiovych |
ORCID |
http://orcid.org/0000-0002-2132-0965 http://orcid.org/0000-0002-4147-6879 http://orcid.org/0000-0002-9805-014X http://orcid.org/0000-0003-4385-3903 http://orcid.org/0000-0002-5274-7021 http://orcid.org/0000-0003-2560-1382 |
Keywords |
мегакаріоцити мегакариоциты megakaryocytes мікроелементоз микроэлементоз microelementosis тромбоцит platelets |
Type | Conference Papers |
Date of Issue | 2019 |
URI | http://essuir.sumdu.edu.ua/handle/123456789/75110 |
Publisher | Springer |
License | |
Citation | Peculiarities of megakaryocytes and platelets variation in the microelementosis condition / Y. Lyndina, V. Sikora, N. Hyriavenko [et al.] // Virchows Archiv. European Journal of Pathology. – 2019. – Vol. 475, Suppl 1. – S. 131. – Pathology: Path to Precision medicine: 31th European Congress of Pathology, 8–12 September 2018, Bilbao, Spain. |
Abstract |
Background & Objectives: The aim of our study was to characterise megakaryocytes and platelets variation under the influence of heavy metal salts and determine the peculiarities of these changes in recovery period. Methods: The laboratory rats (n=48) were used for the conduction of experimental investigation. They were divided into two groups: control – animals which drank clean water and experimental – rats which drank water with heavy metal salts (Zn, Cu, Fe, Mn, Cr and Pb). The bone marrow structure and blood parameters were studied on 30, 90, 120 and 180 day. Results: During 90 days of intoxication the amount of megakaryocytes increased on 40%(р=0.017). There were changes of shape, size (small and giant), nuclear-cytoplasmic ratio, polysegmentation of nuclei and loss of megakaryocyte-sinusoid contacts. It was found the platelets increase by 11% in the blood. Suspending the addition of pollutants to the animal's diet was accompanied by progressive restoration of bone marrow-blood parameters. Simultaneously with disappearance of megakaryocytes morphological variations the area of thrombocytopoiesis was decreased by 28%, the thrombocytes – by 5.3%. Conclusion: The intake of heavy metal salts in elevated concentrations provokes significant disorders in thrombocytopoiesis which leads for platelets increase in the blood. Although there was a significant improvement bone marrow-blood characteristics during recovery period, their values do not reach the indicators of the intact group animals. |
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