Association analysis between BGLAP rs1800247polymorphic variant and type 2 diabetes mellitus development among non-obese Ukrainians

Chumachenko, Y.; Harbuzova, Viktoriia Yuriivna; Zolotova, Svitlana Hryhorivna

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Title	Association analysis between BGLAP rs1800247polymorphic variant and type 2 diabetes mellitus development among non-obese Ukrainians
Authors	Chumachenko, Y. Harbuzova, Viktoriia Yuriivna Zolotova, Svitlana Hryhorivna
ORCID	http://orcid.org/0000-0001-7183-6997 http://orcid.org/0000-0003-1739-8652
Keywords	цукровий діабет 2 типу (ЦД2) розвиток сахарный диабет 2 типа (СД2) развитие type 2 diabetes mellitus (T2DM) development
Type	Conference Papers
Date of Issue	2020
URI	https://essuir.sumdu.edu.ua/handle/123456789/77977
Publisher	Sumy State University
License	Copyright not evaluated
Citation	Chumachenko, Y. Association analysis between BGLAP rs1800247polymorphic variant and type 2 diabetes mellitus development among non-obese Ukrainians [Текст] / Y. Chumachenko, V.Н. Harbuzova, S.H. Zolotova // To Make the World Smarter and Safer: матеріали XIV всеукраїнської науково-практичної конференції студентів, аспірантів та викладачів Лінгвістичного навчально-методичного центру кафедри іноземних мов СумДУ (26 березня 2020 р.) / за заг. ред. Г.І. Литвиненко. – Суми: СумДУ, 2020. – С. 44-45.
Abstract	Type 2 diabetes mellitus (T2DM) belongs to the diseases with hereditary predisposition, so both genetic and environmental factors influence its development. Recent studies showed, that the bone tissue regulates systemic glucose metabolism through the secretion of undercarboxylated osteocalcin (uOCN) into the systemic circulation. It is known, that uOCN binds to the GPRC6A-receptor and, therefore, stimulates insulin expression and secretion in β-cells, as well as increases muscles, liver and adipose tissue sensitivity for insulin. Thus, the thymine to cytosine transition in OCN gene (BGLAP) promoter region (rs1800247) may change the gene expression level and affect T2DM emergence. The aim of the study was to investigate the association between BGLAP rs1800247 single nucleotide polymorphism (SNP) and T2DM development among non-obese Ukrainians.
Appears in Collections:	Наукові видання (ІФСК)