Indicators of left ventricle hypertrophy in patients with arterial hypertension combined with obesity and their interconnection with polymorphism of Lys198Asn genе of endothelin-1

Abstract

Одним із незалежних факторів розвитку серцево-судинних ускладнень є гіпертрофія лівого шлуночка. З кожним роком з’являється все більше публікацій, які доводять, що ця проблема є генетично обумовленою.

Одним из независимых факторов развития сердечно-сосудистых осложнений является гипертрофия левого желудочка. С каждым годом появляется все больше публикаций, доказывающих, что эта проблема является генетически обусловленной.

One of the independent factors of development of cardio-vascular complications is in left ventricular hypertrophy. Each year more and more publication appear that prove this problem is genetically determined. Aim of the study was to find dependence of left ventricular hypertrophy indexes to polymorphism of Les198Asn gene endothelin-1 and BMI. Materials and methods. We took research in 160 patients with arterial hypertension, using ECG and polymerase chain reaction (PCR). Groups were divided additionally according to BMI (body mass index). Results. It was found, that patients with obesity had their Left ventricular mass and hypertrophy left ventricular indexes higher, than in patients with normal and increased body weight. Carriers of Asn198Asn and Lys198Asn genotypes Left ventricular mass and hypertrophy left ventricular indexes are higher than in carriers of Lys198Lys genotype. Conclusions. It was determined that in patients-carriers of Asn198Asn genotype, Left ventricular mass (LVMI) and hypertrophy left ventricular indexes (LVMMI) were higher compared to patients-carriers of Lys198Lys and Lys198Asn type, both in men and women. The dependence of LVMI and LVMMI are shown to be higher in patients with obesity than in people with normal and increased body mass.