PIK3CA-mutant circulating tumor DNA in patients with breast cancer

Vynnychenko, Ihor Oleksandrovych; Pryvalova, Anastasiia Oleksandrivna; Vynnychenko, Oleksandr Ihorovych; Lyndin, Mykola Serhiiovych; Sikora, Vladyslav Volodymyrovych; Romaniuk, Anatolii Mykolaiovych

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Title	PIK3CA-mutant circulating tumor DNA in patients with breast cancer
Other Titles	PIK3CА-мутантная циркулирующая опухолевая ДНК у пациентов с раком молочной железы
Authors	Vynnychenko, Ihor Oleksandrovych Pryvalova, Anastasiia Oleksandrivna Vynnychenko, Oleksandr Ihorovych Lyndin, Mykola Serhiiovych Sikora, Vladyslav Volodymyrovych Romaniuk, Anatolii Mykolaiovych
ORCID	http://orcid.org/0000-0002-2339-6509 http://orcid.org/0000-0002-3445-7303 http://orcid.org/0000-0001-5651-0323 http://orcid.org/0000-0003-4385-3903 http://orcid.org/0000-0002-4147-6879 http://orcid.org/0000-0003-2560-1382
Keywords	PIK3CА рак молочної залози рак молочной железы breast cancer циркулююча пухлинна ДНК циркулирующая опухолевая ДНК circulating tumor DNA
Type	Article
Date of Issue	2020
URI	https://essuir.sumdu.edu.ua/handle/123456789/80853
Publisher	MD Publishing House
License	In Copyright
Citation	Vynnychenko IO, Pryvalova AО, Vynnychenko OI, Lуndіn MS, Sikora VV, Romaniuk AM. PIK3CA-mutant circulating tumor DNA in patients with breast cancer. Azerbaijan Medical Journal (АТJ). 2020;3:79-88. DOI: 10.34921/amj.2020.3.010
Abstract	During the research using digital PCR method, tissue and plasma samples from patients with locally advanced breast cancer were examined for the presence of somatic mutation of PIK3CA in biopsy material and circulating tumor DNA. The presence of PIK3CA gene mutation was detected in 17.24% (5/29) of patients in both biopsy material and plasma. A research of serial samples of patients' plasma revealed changes in the amount of circulating tumor DNA throughout all stages of treatment, which reflected the dynamics of the tumor process. For PIK3CA-mutant breast cancer, ER-positive and Her2/neu-negative tumor phenotypes are characteristic.
Appears in Collections:	Наукові видання (НН МІ)