Positive Association between EDN1 rs5370 (Lys198Asn) Polymorphism and Large Artery Stroke in a Ukrainian Population

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Title	Positive Association between EDN1 rs5370 (Lys198Asn) Polymorphism and Large Artery Stroke in a Ukrainian Population
Authors	Dubovyk, Yevhen Ivanovych Oleshko, Tetiana Bohdanivna Harbuzova, Viktoriia Yuriivna Ataman, Oleksandr Vasylovych
ORCID	http://orcid.org/0000-0002-6720-8397 http://orcid.org/0000-0002-5909-5812 http://orcid.org/0000-0001-7183-6997 http://orcid.org/0000-0002-1941-740X
Keywords	інсульт инсульт stroke
Type	Article
Date of Issue	2018
URI	https://essuir.sumdu.edu.ua/handle/123456789/80871
Publisher	Hindawi ''Disease Markers''
License	In Copyright
Citation	Positive Association between EDN1 rs5370 (Lys198Asn) Polymorphism and Large Artery Stroke in a Ukrainian Population / Ye.I. Dubovyk , T.B. Oleshko, V.Yu. Harbuzova, A.V. Ataman // Disease Markers. - 2018. - Volume 2018. - Article ID 1695782. - 9 pages.
Abstract	As it is well known, endothelial dysfunction plays an important role in the development of common cardiovascular diseases and their complications. One of the main pathogenetic pathways of endothelial dysfunction development is an increased formation and biological activity of the powerful vasoconstrictor and proinflammatory peptide endothelin (ET-1), which mediates own effects via two pharmacologically distinguishable receptor subtypes, endothelin A (ETA) and endothelin B (ETB) receptors, respectively.
Appears in Collections:	Наукові видання (НН МІ)