Microbiological assessment of the clinically significant cultures of the opportunistic microorganisms isolated from the intestines of the patients with Alzheimer’s disease

Abstract

In the microbiological stualy of the intestinal microflora of the patients with Alzheimer’s disease colonization resistance disorders of the mucous membrane af the intestines have been revealed: forming of the multicomponent associations, containing yeast fungi and opportunistie pathogenic bacteria (64.7% of all strains were characterised by the high level of their adhesive). Dysbiotic discorders of the intestinal microflora of the patients with Alzheimer’s disease were followed by authentically low (p <0.05) quamtitative indices of the indigenous microbiota content: Lactobacillus spp. 4.48 ±0.15 lg CFU/g against the background of the III desbiosizs degree; Bifidumbacteium spp. 3.7 ± O.21 CFU/g p — II dvsbiosis degree. In vitro test of Lactobacillus spp. and Bifidumbacteium spp. isolated from the patient with Alzheimer's disease, have not revealed anv strain with a high degree of adhesion and the high “++++ " level of antagonistic activity, concerning opportunistic clinical strains of E.coli, P.vulgaris, K.pneumonias., isolated in the clinically significant concentration.