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Title Morphofunctional reconstructions of the epiphysal-parathyroide axis structural components of rats in the period of readaptation after prolonged exposure to heavy metals
Other Titles Морфофункціональні перебудови структурних компонентів епіфізарно-паратиреоїдної вісі щурів в період реадаптації після довготривалого впливу солей важких металів
Морфофункциональные перестройки структурных компонентов эпифизарно-паратиреоидной оси крыс в период реадаптации после длительного воздействия солей тяжелых металлов
Authors Hryntsova, Nataliia Borysivna  
Tymakova, Olena Oleksandrivna
Romaniuk, Anatolii Mykolaiovych  
ORCID http://orcid.org/0000-0002-6713-7533
http://orcid.org/0000-0003-2560-1382
Keywords епіфіз
эпифиз
epiphys
щури
крысы
rats
важкі метали
тяжелые металлы
heavy metals
Type Article
Date of Issue 2020
URI https://essuir.sumdu.edu.ua/handle/123456789/82020
Publisher V. Danilevsky institute for endocrine pathology problems of the NAMS of Ukraine
License Creative Commons Attribution 4.0 International License
Citation Hryntsova N. B., Tymakova О. О., Romaniuk A. M. Morphofunctional reconstructions of the epiphysal-parathyroide axis structural components of rats in the period of readaptation after prolonged exposure to heavy metals // Problems of Endocrine Pathology. - 2020. - №4. - C. 106-114. DOI: https://doi.org/10.21856/j-PEP.2020.4.14.
Abstract An important environmental problem is the pollution of the environment with heavy metal salts, which are in various combinations depending on the region and cause adverse effects on public health. The endocrine system together with the immune and nervous system maintains homeostasis in the body. In order to study the morphofunctional rearrangements of the epiphyseal-parathyroid axis structural components in rats during 30 days of readaptation after 90 days of exposure to heavy metal salts (zinc (ZnSO4 · 7H2O) — 5 mg/l, copper (CuSO4 · 5H2O) — 1 mg/l, iron (FeSO4 ) — 10 mg/l, manganese (MnSO4 · 5H2O) — 0.1 mg/l, lead (Pb(NO3 ) 2 ) — 0.1 mg/l and chromium K2Cr2O7) — 0.1 mg/l) an experiment was performed on 24 white sexually mature male rats weighing 250–300 g, aged 7–8 months. The animals of the experimental group consumed ordinary drinking water for 30 days. Morphological, statistical, immunohistochemical and biochemical research methods were used. The 30-day period of readaptation after 90 days of heavy metal salts intake is insufficient to completely restore homeostasis in the epiphyseal-parathyroid system, which is at the stage of chronic stress «subcompensation». Significant morphological changes on the part of the vascular bed of the pineal gland and parathyroid glands (blood stasis, erythrocyte aggregation, sludge phenomenon) were determined, an active glial reaction was formed in the pineal gland, and the structure of the epithelial trabeculae of the glands was disturbed. The levels of parathyroid hormone and calcium in the blood of experimental animals were significantly lower than those of experimental animals. There is a greater vulnerability and faster dynamics of the regenerative processes in the parathyroid glands to the action of salts of heavy metals in comparison with the pineal gland. The development of hypofunction of the parathyroid glands, of course, has a negative effect on the overall calcium metabolism in the body, the development of compensatory and adaptive processes and the course of the general adaptation syndrome in response to the damaging agent.
Appears in Collections: Наукові видання (НН МІ)

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