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Title | Complementary Effect of Non-Persistent Silver Nano- Architectures and Chlorhexidine on Infected Wound Healing |
Authors |
Pernakov, Mykola Stanislavovych
Ermini, M.L. Sulaieva, O. Cassano, D. Santucci, M. Husak, Yevheniia Volodymyrivna Korniienko, Viktoriia Volodymyrivna Korniienko, Viktoriia Volodymyrivna Giannone, G. Yusupova, Aziza Farkhodivna Liubchak, Iryna Volodymyrivna Hristova, M.T. Savchenko, A. Holubnycha, Viktoriia Mykolaivna Voliani, V. Pohorielov, Maksym Volodymyrovych |
ORCID |
http://orcid.org/0000-0002-7048-7446 http://orcid.org/0000-0002-2217-3717 http://orcid.org/0000-0002-5144-2138 http://orcid.org/0000-0002-1241-2550 http://orcid.org/0000-0001-9372-7791 |
Keywords |
antimicrobials surgical site infections silver nanomaterials wound healing |
Type | Article |
Date of Issue | 2021 |
URI | https://essuir.sumdu.edu.ua/handle/123456789/86267 |
Publisher | MDPI |
License | Creative Commons Attribution 4.0 International License |
Citation | Pernakov, M.; Ermini, M.L.; Sulaieva, O.; Cassano, D.; Santucci, M.; Husak, Y.; Korniienko, V.; Giannone, G.; Yusupova, A.; Liubchak, I.; Hristova, M.T.; Savchenko, A.; Holubnycha, V.; Voliani, V.; Pogorielov, M. Complementary Effect of Non-Persistent Silver Nano-Architectures and Chlorhexidine on Infected Wound Healing. Biomedicines 2021, 9, 1215. https://doi.org/10.3390/biomedicines9091215 |
Abstract |
Surgical site infection (SSI) substantially contributes each year to patients’ morbidity and mortality, accounting for about 15% of all nosocomial infections. SSI drastically increases the rehab stint and expenses while jeopardizing health outcomes. Besides prevention, the treatment regime relies on an adequate antibiotic therapy. On the other hand, resistant bacterial strains have currently reached up to 34.3% of the total infections, and this percentage grows annually, reducing the efficacy of the common treatment schemes. Thus, new antibacterial strategies are urgently demanded. Here, we demonstrated in rats the effectiveness of non-persistent silver nano-architectures (AgNAs) in infected wound healing together with their synergistic action in combination with chlorhexidine. Besides the in vivo efficacy evaluation, we performed analysis of the bacteriological profile of purulent wound, histological evaluations, and macrophages polarization quantifications to further validate our findings and elucidate the possible mechanisms of AgNAs action on wound healing. These findings open the way for the composition of robust multifunctional nanoplatforms for the translation
of safe and efficient topical treatments of SSI. |
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Pernakov_et.al_Complementary_Effect.pdf | 3.69 MB | Adobe PDF | -572878963 |
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