The Expression of Prolactin Receptors in Benign Breast Tumors Is Not Associated with Serum Prolactin Level

Kolomiiets, Olena Olehivna; Yazykov, Oleksandr Valeriiovych; Piddubnyi, Artem Mykhailovych; Lyndin, Mykola Serhiiovych; Lukavenko, Ivan Mykhailovych; Andriushchenko, Volodymyr Viktorovych; Romaniuk, Anatolii Mykolaiovych; Moskalenko, Roman Andriiovych

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Title	The Expression of Prolactin Receptors in Benign Breast Tumors Is Not Associated with Serum Prolactin Level
Authors	Kolomiiets, Olena Olehivna Yazykov, Oleksandr Valeriiovych Piddubnyi, Artem Mykhailovych Lyndin, Mykola Serhiiovych Lukavenko, Ivan Mykhailovych Andriushchenko, Volodymyr Viktorovych Romaniuk, Anatolii Mykolaiovych Moskalenko, Roman Andriiovych
ORCID	http://orcid.org/0000-0002-6464-4839 http://orcid.org/0000-0003-3528-9265 http://orcid.org/0000-0002-6508-0131 http://orcid.org/0000-0003-4385-3903 http://orcid.org/0000-0003-1302-1698 http://orcid.org/0000-0003-2560-1382 http://orcid.org/0000-0002-2342-0337
Keywords	пролактин prolactin рецептори пролактину рецепторы пролактина prolactin receptors доброякісні пухлини грудної залози доброкачественные опхоли грудной железы benign breast tumors
Type	Article
Date of Issue	2021
URI	https://essuir.sumdu.edu.ua/handle/123456789/86327
Publisher	MDPI
License	Creative Commons Attribution 4.0 International License
Citation	Kolomiiets, O.; Yazykov, O.; Piddubnyi, A.; Lyndin, M.; Lukavenko, I.; Andryushchenko, V.; Romaniuk, A.; Moskalenko, R. The Expression of Prolactin Receptors in Benign Breast Tumors Is Not Associated with Serum Prolactin Level. J. Clin. Med. 2021, 10, 5866. https://doi.org/10.3390/jcm10245866.
Abstract	The role of prolactin (PRL) and its receptors in the initiation and development of benign breast tumors (BBT) has not been sufficiently studied. An imbalance in the system of hormone homeostasis is crucial in the development of BBT. In particular, an association between elevated prolactin levels and the development of BBT has been reported. Our study showed no significant differences between PRL receptor (PRL-R) expression in BBT tissue under normal and elevated serum PRL levels. There was also no significant correlation between age, PRL-R expression in BBT tissue, intact tissue, and PRL level in the serum. There was a strong significant correlation (p < 0.01; r = 0.92) between PRL-R expression in BBT samples and intact breast tissue, which did not depend on the serum PRL level. There was also no significant difference in the expression of the proliferative marker Ki-67 in BBT tissues from women with normal and elevated levels of serum PRL (p > 0.05). No signs of PRL and its receptors were detected in the BBT cystic fluid women with elevated serum PRL levels. In summary, our prospective study showed that the expression of PRL-R in the tissue of BBT and physiological breast tissue does not depend on the level of serum PRL.
Appears in Collections:	Наукові видання (НН МІ)