Coronary artery disease association with serum concentration and genetic variation of MMP-9 in Ukrainian population

Pohorielova, Oksana Serhiivna; Chumachenko, Y.A.; Obukhova, Olha Anatoliivna; Martsovenko, I.; Harbuzova, Viktoriia Yuriivna

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Title	Coronary artery disease association with serum concentration and genetic variation of MMP-9 in Ukrainian population
Authors	Pohorielova, Oksana Serhiivna Chumachenko, Y.A. Obukhova, Olha Anatoliivna Martsovenko, I. Harbuzova, Viktoriia Yuriivna
ORCID	http://orcid.org/0000-0003-4077-8637 http://orcid.org/0000-0002-2104-8412 http://orcid.org/0000-0001-7183-6997
Keywords	Epidemiology Prognosis Outcome
Type	Conference Papers
Date of Issue	2021
URI	https://essuir.sumdu.edu.ua/handle/123456789/87549
Publisher	European Society of Cardiology
License	Creative Commons Attribution 4.0 International License
Citation	O Pogorielova, Y A Chumachenko, O Obukhova, I Martsovenko, V Harbuzova, Coronary artery disease association with serum concentration and genetic variation of MMP-9 in Ukrainian population, European Heart Journal, Volume 42, Issue Supplement_1, October 2021, ehab724.1338, https://doi.org/10.1093/eurheartj/ehab724.1338
Abstract	Coronary artery disease (CAD) is one of the main cause of death in European countries. The mortality associated with CAD has been rising for the past 30 years in Central and Easten Europe (including Ukraine). It is known that atherosclerosis is the primary risk factor of CAD development and Matrix metalloproteinase-9 (MMP-9) is involved in all stages of atherosclerosis and thus may contribute to CAD aggravation. It is very important to find specific mechanisms of atherosclerosis progression, the impact of genetic and external factors which influence on the development of CAD in different populations. Therefore, the aim of this study was to investigate the influence of MMP-9 concentration and functional rs17576 single nucleotide polymorphism (SNP) on risk of CAD development in Ukrainian population.
Appears in Collections:	Наукові видання (НН МІ)