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Title | Morphological features of tubular bones reparative regeneration under the influence of antitumor chemotherapeutics |
Authors |
Riabenko, Tetiana Vasylivna
Korenkov, Oleksii Volodymyrovych Dmytruk, Serhii Mykolaiovych Yarmolenkо, Olha Serhiivna Ponyrko, Alina Oleksiivna Pernakov, Mykola Stanislavovych Hula, Viktoriia Ivanivna |
ORCID |
http://orcid.org/0000-0003-2740-389X http://orcid.org/0000-0002-1314-5642 http://orcid.org/0000-0001-6434-2817 http://orcid.org/0000-0002-7872-2308 http://orcid.org/0000-0002-1799-7789 http://orcid.org/0000-0002-7048-7446 http://orcid.org/0000-0003-3869-5162 |
Keywords |
reparative regeneration bone antitumor chemotherapeutics |
Type | Article |
Date of Issue | 2022 |
URI | https://essuir.sumdu.edu.ua/handle/123456789/87865 |
Publisher | Aluna Publishing |
License | Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International |
Citation | Riabenko ТV, Korenkov OV, Dmytruk SM, Yarmolenko OS, Ponurko AA, Pernakov MS, Gula VI. MORPHOLOGICAL FEATURES OF TUBULAR BONES REPARATIVE REGENERATION UNDER THE INFLUENCE OF ANTITUMOR CHEMOTHERAPEUTICS. Wiad Lek. 2022;75(3):570-576. |
Abstract |
The aim: Determination of morphological features of reparative regeneration of diaphysis defect of long tubular bones under the influence of antitumor chemotherapeutics in a model experiment.
Materials and methods: 96 white nonlinear rats after application of the perforated defect of the femur were administered the appropriate antitumor drug (doxorubicin, 5-fluorouracil, methotrexate) three times with an interval of 21 days. Morphological features of bone tissue formation and remodeling in the regenerate area were studied using histological and morphometric methods.
Results: The inhibitory effect of antitumor chemotherapeutics on the formation of regenerate, expressed by slowing down the process of bone tissue differentiation was found.
This is confirmed by a decrease in the area of reticulofibrous and lamellar bone tissue, chaotic arrangement and narrowing of bone trabeculae with uneven color, slow formation of bonding lines between the maternal bone and the regenerate.
Conclusions: The revealed morphological features of reparative regeneration of the diaphysis defect of long tubular bones under the influence of antitumor chemotherapeutics doxorubicin, 5-fluorouracil and methotrexate in a model experiment indicate a slowing of reparative regeneration processes at all stages of recovery after injury. |
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