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Title Serum levels of IL-2 and IL-17A are related to clinical type and severity of alopecia areata
Authors Aldzhabali, Mokhammad Azhar Mokhammad  
Kuts, Larysa Viktorivna  
ORCID http://orcid.org/0000-0002-0092-6319
http://orcid.org/0000-0002-9740-0718
Keywords alopecia areata
interleukin
SALT
serum
Th1
Th17
Type Article
Date of Issue 2022
URI https://essuir.sumdu.edu.ua/handle/123456789/87968
Publisher Aluna Publishing
License Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International
Citation Aljabali MA, Kuts L. SERUM LEVELS OF IL-2 AND IL-17A ARE RELATED TO CLINICAL TYPE AND SEVERITY OF ALOPECIA AREATA. Wiad Lek. 2022;75(1 pt 2):263-267.
Abstract The aim: To check the link between interleukins serum levels (IL-2, IL-10, IL-17A) and alopecia areata (AA) development, severity, and clinical course. Materials and methods: Totally 104 patients with AA and 30 matched control individuals were enrolled in the study. The serum levels of IL-2, IL-10, and IL-17A were evaluated in all participants. Severity of Alopecia Tool (SALT) was used to assess the AA severity. The SPSS 22.0 and Python environment were used for statistical analysis. Results: The comparative analysis has demonstrated that the serum levels of IL-2 and IL-17A in AA patients are higher than in controls (P = 0.008 and P = 0.013, respectively). The blood level of IL-2 in patients with AA depends on disease severity (P = 0.006) and clinical subtype (P = 0.016). The serum concentration of IL-17A was also associated with AA severity (P = 0.010) and subtype (P = 0.004). The positive correlation between SALT score and serum level of IL-17A (r = 0.33, P = 0.001) and IL-2 (r = 0.28, P = 0.004) was revealed. The strong positive correlation between IL-17A and IL-2 was also detected (r = 0.49, P < 0.001). There was no link between AA occurrence, manifestation and IL-10 amount. However, the weak negative correlation between SALT and IL-10 serum level was revealed (r = -0.20, P = 0.042). Conclusions: Our findings demonstrated that the serum levels of IL-2 and IL-17A are intercorrelated and associated with AA development, severity, and clinical type. The link between IL-10 serum level and AA was not detected.
Appears in Collections: Наукові видання (НН МІ)

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