Вплив ангіопротекторів на розвиток кальцієвих і електролітно-осмотичних механізмів ушкодження тканин кровоносних судин у патогенезі гіперадреналінового артеріосклерозу

Abstract

The effect of angioprotectors with different mechanisms of action on the alterations of calcium content in blood serum, as well as on the alterations of volume of inulin space, of water and calcium content in walls of different blood vessels at progress of hyperadrenalinaemia were studied. A maximal level of sensitivity to hyperadrenaline injure of thoracic aorta tissues, intermediate level of injure of abdominic aorta and pulmonic arteria, and minimal level of injure of vena cava posterior were discovered. It is discovered that the blocker of calcium channels (nifedipine) cause maximal decrease of the degree of violations of water-electrolytic and calcium metabolism in blood vessel wall in progress of the hyperadrenaline arteriosclerosis, antioxidant (vitamin E) has moderate effect, and the complex former (diphosphonic acid) - has minimal effect in this respect. The obtained results testify that quite direct and tight interrelations between lipid and calcium mechanisms of injure of blood vessel tissues exist in progress of the hyperadrenaline arteriosclerosis; and also that intracellular free radical processes and calcium-dependent reactions cause much greater violations of water-electrolytic and calcium metabolism in vessel wall tissues than extracellular reactions do. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/892