The Prospects of Using Structural Phase Analysis of Microcalcifications in Breast Cancer Diagnostics

Piddubnyi, Artem Mykhailovych; Kolomiiets, Olena Olehivna; Danylchenko, Serhii Mykolaiovych; Stepanenko, Andrii Oleksandrovych; Moskalenko, Yuliia Vasylivna; Moskalenko, Roman Andriiovych

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Title	The Prospects of Using Structural Phase Analysis of Microcalcifications in Breast Cancer Diagnostics
Authors	Piddubnyi, Artem Mykhailovych Kolomiiets, Olena Olehivna Danylchenko, Serhii Mykolaiovych Stepanenko, Andrii Oleksandrovych Moskalenko, Yuliia Vasylivna Moskalenko, Roman Andriiovych
ORCID	http://orcid.org/0000-0002-6508-0131 http://orcid.org/0000-0002-6464-4839 http://orcid.org/0000-0003-0105-0440 http://orcid.org/0000-0002-5398-0298 http://orcid.org/0000-0002-2342-0337
Keywords	breast cancer microcalcification phase analysis
Type	Article
Date of Issue	2023
URI	https://essuir.sumdu.edu.ua/handle/123456789/91007
Publisher	MDPI
License	Creative Commons Attribution 4.0 International License
Citation	Piddubnyi, A.; Kolomiiets, O.; Danilchenko, S.; Stepanenko, A.; Moskalenko, Y.; Moskalenko, R. The Prospects of Using Structural Phase Analysis of Microcalcifications in Breast Cancer Diagnostics. Diagnostics 2023, 13, 737. https://doi.org/10.3390/diagnostics13040737
Abstract	The detection of microcalcifications in the breast by mammography is of great importance for the early diagnostics of breast cancer. This study aimed to establish the basic morphological and crystal-chemical properties of microscopic calcifications and their impact on breast cancer tissue. During the retrospective study, 55 out of 469 breast cancer samples had microcalcifications. The expression of the estrogen and progesterone receptors and Her2-neu showed no significant difference from the non-calcified samples. An in-depth study of 60 tumor samples revealed a higher osteopontin expression in the calcified breast cancer samples (p < 0.01). The mineral deposits had a hydroxyapatite composition. Within the group of calcified breast cancer samples, we detected six cases of colocalization of oxalate microcalcifications together with biominerals of the usual “hydroxyapatite” phase composition. The simultaneous presence of calcium oxalate and hydroxyapatite was accompanied by a different spatial localization of microcalcifications. Thus, the phase compositions of microcalcifications could not be used as criteria for the differential diagnostics of breast tumors.
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