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Title | Case report: Metastasis of Merkel cell carcinoma in the small intestine |
Authors |
Chyzhma, Ruslana Anatoliivna
Piddubnyi, Artem Mykhailovych Romaniuk, Anatolii Mykolaiovych Moskalenko, Roman Andriiovych |
ORCID |
http://orcid.org/0000-0002-6508-0131 http://orcid.org/0000-0003-2560-1382 http://orcid.org/0000-0002-2342-0337 |
Keywords |
карцинома Меркеля Merkel cell carcinoma метастаз metastasis тонка кишка тонкая кишка small intestine |
Type | Article |
Date of Issue | 2023 |
URI | https://essuir.sumdu.edu.ua/handle/123456789/91730 |
Publisher | Elsevier |
License | Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International |
Citation | R. Chyzhma, A. Piddubnyi, A. Romaniuk, R. Moskalenko, Case report: Metastasis of Merkel cell carcinoma in the small intestine. Pathology - Research and Practice. 248 (2023) 154594. https://doi.org/10.1016/j.prp.2023.154594 |
Abstract |
Merkel cell carcinoma is a rare primary neuroendocrine malignant neoplasm of the skin, which recurs in about
40 % of cases. The main factors are Merkel cell polyomavirus (MCPyV) and mutations caused by ultraviolet
radiation [Paulson, 2018]. In this study, we report a case of Merkel cell carcinoma with metastasis to the small
intestine. In a 52-year-old woman, a subcutaneous formation of a nodule up to 2.0 cm in diameter was detected
during the examination. This neoplasm was removed and sent for histological analysis. Dot-like expression of CK
pan, CK 20, chromogranin A, and Synaptophysin was observed in tumor cells, and Ki-67 in 40 % of tumor cells.
There is no reaction in tumor cells to CD 45, CK 7, TTF 1, and S100. The morphological picture corresponded to
Merkel cell carcinoma. A year later, the patient underwent surgery for intestinal obstruction. The pathohistological changes and immunophenotype of the small bowel tumor were consistent with Merkel cell carcinoma
metastasis. |
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