Evaluation of methotrexate toxicity

Рябенко, Тетяна Василівна; Гула, Вікторія Іванівна; Кореньков, Олексій Володимирович; Понирко, Аліна Олексіївна; Теслик, Тетяна Петрівна; Дмитрук, Сергій Миколайович; Ілляшенко, Вячеслав Юрійович; Illiashenko, Viacheslav Yu.; Дудченко, Євгеній Сергійович

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Title	Evaluation of methotrexate toxicity
Authors	Riabenko, Tetiana Vasylivna Hula, Viktoriia Ivanivna Korenkov, Oleksii Volodymyrovych Ponyrko, Alina Oleksiivna Teslyk, Tetiana Petrivna Dmytruk, Serhii Mykolaiovych Illiashenko, Viacheslav Yuriiovych Illiashenko, Viacheslav Yu. Dudchenko, Yevhenii Serhiiovych
ORCID	http://orcid.org/0000-0003-2740-389X http://orcid.org/0000-0003-3869-5162 http://orcid.org/0000-0002-1314-5642 http://orcid.org/0000-0002-1799-7789 http://orcid.org/0000-002-5832-7415 http://orcid.org/0000-0001-6434-2817 http://orcid.org/0000-0002-9929-1287 http://orcid.org/0000-0002-1737-1735
Keywords	methotrexate toxisity side effects clinical evaluation bone marrow disease teratogenesis digestive system disease embryotoxicity skin disease lung disease liver disease kidney disease
Type	Article
Date of Issue	2023
URI	https://essuir.sumdu.edu.ua/handle/123456789/95266
Publisher	Izdatel'stvo Elm
License	Creative Commons Attribution 4.0 International License
Citation	Riabenko T. V., Hula V. I., Korenkov O. V., Ponyrko A. A., Teslyk T. P. et al. Evaluation of methotrexate toxicity. Azerbaijan Medical Journal. 2023;(4).141-146. DOI: 10.34921/amj.2023.4.020.
Abstract	The article analyzes literary sources on the study of the toxic effects of methotrexate in the treatment of various diseases and examines scientific data on methods of preventing their development. According to the literary information, the main toxic effects of methotrexate manifest as damage to the liver, kidneys, bone marrow, lungs, digestive system, and skin. Methotrexate exhibits pronounced embryotoxic and teratogenic effects. Monitoring of blood test parameters and selection of an optimal dose will minimize methotrexate toxic effects and help in achieving success in the treatment.
Appears in Collections:	Наукові видання (НН МІ)