Влияние лекарственных средств с различными механизмами действия на концентрацию эпихлоргидрина в биологических средах организмав условиях острой интоксикации летучими компонентами эпоксидной смолы ЭД 20

Abstract

In the experiments on white rat-males line Wistar 150-200 gr. weight in the conditions of acute 4-hour dynamic ingalating intoxication by the flying compounds of epoxyde resine ED-20 (ER) - studied some toxicokinetics’ parameters of leader and the most toxic flying compound of ER - epichlorhydrine (ECH). For correction of ECH level in the blood serum, we used before and after intoxication quercetine (350 mg/kg), flavinate (4 mg/kg), lipine (0,8 mmol/kg), nicotinamide (260 mg/kg), acetylcysteine (450 mg/ kg) and before intoxication - inductor of epoxihydrolase omeprasole (50 mg/kg) and clofibrate (200 mg/kg). Showed that ECH is differ from very high bioaccessible long circulate in the blood serum and rich the maximum concentration on the 6-th hour after intoxication. Excretion of ECH with urine realize in comparatively low concentrations as for those which definited in the blood serum and slowly increase by the 3-d day of experiment. For decreasing degree of ECH in the blood serum - used pharmacological substances are perfomed in the next order: flavinate > omeprasole > acetylcysteine > clofibrate > quercetine > lipine > nicotinamide. Quercetine, lipine, acetylcysteine parallel to decreasing of poison containing in the blood reliable increase it’s excretion with urine. Decreasing of ECH concentration in the blood under the influence of flavinate, clofibrate, omeprasole and in a bit slighter degree - nicotinamide - followed the parallel decreasing of it’s excretion with urine, that bear about acceleration of biotransformation of poison in the body under those substances. In this work we discuss the pacularities of modificative influence used medicines on the toxicokinetics of ECH under the acute intoxication by ER. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/1888