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Title | Development and Investigation of Emulsion Form for Antiepileptic Drug Carbamazepine |
Authors |
Prokhorov, D.I.
Antyasova, M.N. Groza, N.V. Kapitza, I.G. |
ORCID | |
Keywords |
Carbamazepine Nanoemulsion Anticonvulsant activity Epilepsy Parenteral formulation Drug solubilization |
Type | Article |
Date of Issue | 2014 |
URI | http://essuir.sumdu.edu.ua/handle/123456789/37238 |
Publisher | Sumy State University |
License | |
Citation | Proc. NAP 3, 02NABM02 (2014) |
Abstract |
This study was directed to obtain a carbamazepine nanoemulsion for intravenous administration which consists of medium-chain trigycerides (Myritol) used as oil phase and Tween 80 as emulsifier. The spontaneous emulsification method with additional sonication was used to prepare different formulation containing 0.5 mg/ml carbamazepine. The nanoemulsions were evaluated concerning droplet size, zeta potential and drug content. Preliminary studies of anticonvulsant activity for resulting formulation were carried out. |
Appears in Collections: |
Наукові видання (ЕлІТ) |
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File | Size | Format | Downloads |
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prokhorov_epilepsy.pdf | 321,11 kB | Adobe PDF | 57545993 |
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