Development and Investigation of Emulsion Form for Antiepileptic Drug Carbamazepine

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Title	Development and Investigation of Emulsion Form for Antiepileptic Drug Carbamazepine
Authors	Prokhorov, D.I. Antyasova, M.N. Groza, N.V. Kapitza, I.G.
Keywords	Carbamazepine Nanoemulsion Anticonvulsant activity Epilepsy Parenteral formulation Drug solubilization
Type	Article
Date of Issue	2014
URI	http://essuir.sumdu.edu.ua/handle/123456789/37238
Publisher	Sumy State University
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Citation	Proc. NAP 3, 02NABM02 (2014)
Abstract	This study was directed to obtain a carbamazepine nanoemulsion for intravenous administration which consists of medium-chain trigycerides (Myritol) used as oil phase and Tween 80 as emulsifier. The spontaneous emulsification method with additional sonication was used to prepare different formulation containing 0.5 mg/ml carbamazepine. The nanoemulsions were evaluated concerning droplet size, zeta potential and drug content. Preliminary studies of anticonvulsant activity for resulting formulation were carried out.
Appears in Collections:	Наукові видання (ЕлІТ)