Please use this identifier to cite or link to this item: http://essuir.sumdu.edu.ua/handle/123456789/70534
Or use following links to share this resource in social networks: Recommend this item
Title Morphological analysis of papillary thyroid carcinoma with psammoma bodies
Authors Romaniuk, Anatolii Mykolaiovych  
Moskalenko, Roman Andriiovych  
Yashchishyn, Ihor Oleksandrovych  
Sukhariev, Anatolii Borysovych
Piddubnyi, Artem Mykhailovych  
Rieznik, Andrii Vasylovych
Morozova-Roche, L.
ORCID http://orcid.org/0000-0003-2560-1382
http://orcid.org/0000-0002-2342-0337
http://orcid.org/0000-0002-1691-9025
http://orcid.org/0000-0002-6508-0131
Keywords папілярний рак щитоподібної залози
папиллярный рак щитовидной железы
papillary thyroid carcinoma
імуногістохімія
иммуногистохимия
immunohistochemistry
псамомні тільця
псамомные тельца
psammoma bodies
остеопонтин
osteopontin
Type Conference Papers
Date of Issue 2018
URI http://essuir.sumdu.edu.ua/handle/123456789/70534
Publisher Virchows Archiv
License
Citation Morphological analysis of papillary thyroid carcinoma with psammoma bodies [Text] / A. Romaniuk, R. Moskalenko, I. Iashchishyn [et al.] // Virchows Archiv. – 2018. – № 473. – P. S251-S252.
Abstract Background & Objective: During last decade, the proportion of thyroid cancer, among other types of cancer had a clear tendency to rise. Papillary thyroid carcinoma (PTC) is the most common cancer of this organ, constituting up to ca. 70% cases. For the majority of patients the general survival rate depends on the histological features of the tumour and on many other predictors, one of which is pathological biomineralization. The aim of the work is to carry out morphological analysis of the tissues papillary thyroid carcinoma with psammoma bodies. Method: We have analysed the samples from 54 PTC patients and controls by using immunohistochemistry and spectroscopic techniques. The samples were divided into two groups: the PTC group included 24 cases of PTC with psammoma bodies and the control group was constituted of 30 PTC cases without psammoma bodies and other manifestations of pathological biomineralization. Results: We have demonstrated the clear colocalization of osteopontin and calprotectin in the psammoma bodies and suggested the model for their laminated structure development. Immunostaining with of activated Caspase 3 antibodies revealed significantly higher number of apoptotic cells in the samples of PTC with PBs. Conclusion: We have found intensive immunostaining with osteopontin antibodies in the tumour tissues and in the tumour surrounding, which indicates that osteopontin may counteract biomineralization. We have shown that the major component of PBs is hydroxyapatite.
Appears in Collections: Наукові видання (НН МІ)

Views

Belarus Belarus
1
Côte d’Ivoire Côte d’Ivoire
1
Germany Germany
1
Greece Greece
1
Ireland Ireland
786761
Lithuania Lithuania
1
Netherlands Netherlands
956
Pakistan Pakistan
1
Portugal Portugal
1
Singapore Singapore
696873785
Sweden Sweden
5260
Ukraine Ukraine
124566629
United Kingdom United Kingdom
62284272
United States United States
696873783
Unknown Country Unknown Country
36265378
Vietnam Vietnam
10522

Downloads

Ireland Ireland
1
Lithuania Lithuania
1
Portugal Portugal
1
Ukraine Ukraine
124566630
United Kingdom United Kingdom
1
United States United States
472953998
Unknown Country Unknown Country
14
Vietnam Vietnam
1

Files

File Size Format Downloads
Piddubnyi_PTC.pdf 73,49 kB Adobe PDF 597520647

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.