Investigative utility ofmicrosatlite genotyping for molar pregnancy testing

Abstract

Hydatidiform mole also known as hydatid mole, molar pregnancy, gestational trophoblastic disease is a type of fertilization abnormality, when only the conceptus trophoblast layers proliferates and not the embryoblast, no embryo develops, this is called a “Hydatidiform mole". Due to the continuing presence of the trophoblastic layer, this abnormal conceptus can also implant in the uterus or ectopically. The trophoblast cells will secrete human chorionic gonadotropin (hCG), as in a normal pregnancy, and may appear maternally and by pregnancy test to be "normal". Prenatal diagnosis by ultrasound analysis demonstrates the absence of an embryo.