Приходько, Ольга ОлексіївнаPrykhodko, Olha OleksiivnaAvilova, O.Дмитрук, Сергій МиколайовичDmytruk, Serhii MykolaiovychПонирко, Аліна ОлексіївнаPonyrko, Alina OleksiivnaГордієнко, Олена ВолодимирівнаHordiienko, Olena VolodymyrivnaPrykhodko, E.2023-12-212023-12-212023Prykhodko O, Avilova O, Dmytruk S, Ponyrko A, Gordienko O, Prykhodko E. Histoultrastructural features of thymocytes due to t he impact of the experimental general dehydration of a mild degree // Wiadomości Lekarskie Medical Advances. 2023. № 76(8). С. 1709-1716.0000-0001-6434-28170000-0002-1799-77890000-0002-9408-8415https://essuir.sumdu.edu.ua/handle/123456789/93782ABSTRACT The aim: The objective of the current study was to reveal ultrastructural changes in rats’ thymocytes in experimental data in conditions of mild general dehydration. Materials and methods: The study was conducted on 20 non-linear adult male laboratory rats weighing 150-170 g. Histological and semi-thin slides of the thymus were prepared according to the required guidelines. Results: On average, in the cortical zone of the thymus, there was decreased cellularity by 13.4% (p<0.001), while in the medulla zone this indicator turned out to be unreliable - 5.5% (р=0.19), compared to the indicators in animals of the control group. The study showed that a slight degree of general dehydration of the body causes ultrastructural changes in the thymus and is accompanied by a cell-mediated response of the central link of immunogenesis and results in morphological changes in the thymus, which are atrophic in nature with a typical pattern of remodeling of the organ’s microstructure, which corresponds to cellular aging and the associated sign of accelerated involution. Conclusions: General dehydration of a mild degree in the experiment is accompanied by a cell-mediated response of the central link of immunogenesis and results in morphological changes in the thymus, which are atrophic in nature with a typical pattern of remodeling of the organ’s microstructure, which corresponds to cellular aging and the associated sign of accelerated involution.enCC BY-NC-ND 4.0щурratвилочкова залозаthymus glandгістологіяhistologyультраструктураultrastructureекспериментexperimentArticle