Дубовик, Євген ІвановичДубовик, Евгений ИвановичDubovyk, Yevhen IvanovychОлешко, Тетяна БогданівнаОлешко, Татьяна БогдановнаOleshko, Tetiana BohdanivnaГарбузова, Вікторія ЮріївнаГарбузова, Виктория ЮрьевнаHarbuzova, Viktoriia YuriivnaАтаман, Олександр ВасильовичАтаман, Александр ВасильевичAtaman, Oleksandr Vasylovych2020-12-032020-12-032018Positive Association between EDN1 rs5370 (Lys198Asn) Polymorphism and Large Artery Stroke in a Ukrainian Population / Ye.I. Dubovyk , T.B. Oleshko, V.Yu. Harbuzova, A.V. Ataman // Disease Markers. - 2018. - Volume 2018. - Article ID 1695782. - 9 pages.0000-0002-5909-58120000-0001-7183-69970000-0002-1941-740X0000-0002-6720-8397https://essuir.sumdu.edu.ua/handle/123456789/80871As it is well known, endothelial dysfunction plays an important role in the development of common cardiovascular diseases and their complications. One of the main pathogenetic pathways of endothelial dysfunction development is an increased formation and biological activity of the powerful vasoconstrictor and proinflammatory peptide endothelin (ET-1), which mediates own effects via two pharmacologically distinguishable receptor subtypes, endothelin A (ETA) and endothelin B (ETB) receptors, respectively.eninc10інсультинсультstrokeArticle