Чижма, Руслана АнатоліївнаЧижма, Руслана АнатольевнаChyzhma, Ruslana AnatoliivnaПіддубний, Артем МихайловичПоддубный, Артем МихайловичPiddubnyi, Artem MykhailovychРоманюк, Анатолій МиколайовичРоманюк, Анатолий НиколаевичRomaniuk, Anatolii MykolaiovychМоскаленко, Роман АндрійовичМоскаленко, Роман АндреевичMoskalenko, Roman Andriiovych2023-06-092023-06-092023R. Chyzhma, A. Piddubnyi, A. Romaniuk, R. Moskalenko, Case report: Metastasis of Merkel cell carcinoma in the small intestine. Pathology - Research and Practice. 248 (2023) 154594. https://doi.org/10.1016/j.prp.2023.1545940000-0002-2342-03370000-0002-6508-01310000-0003-2560-1382https://essuir.sumdu.edu.ua/handle/123456789/91730Merkel cell carcinoma is a rare primary neuroendocrine malignant neoplasm of the skin, which recurs in about 40 % of cases. The main factors are Merkel cell polyomavirus (MCPyV) and mutations caused by ultraviolet radiation [Paulson, 2018]. In this study, we report a case of Merkel cell carcinoma with metastasis to the small intestine. In a 52-year-old woman, a subcutaneous formation of a nodule up to 2.0 cm in diameter was detected during the examination. This neoplasm was removed and sent for histological analysis. Dot-like expression of CK pan, CK 20, chromogranin A, and Synaptophysin was observed in tumor cells, and Ki-67 in 40 % of tumor cells. There is no reaction in tumor cells to CD 45, CK 7, TTF 1, and S100. The morphological picture corresponded to Merkel cell carcinoma. A year later, the patient underwent surgery for intestinal obstruction. The pathohistological changes and immunophenotype of the small bowel tumor were consistent with Merkel cell carcinoma metastasis.enCC BY-NC-ND 4.0карцинома МеркеляMerkel cell carcinomaметастазmetastasisтонка кишкатонкая кишкаsmall intestineArticle