Сікора, Владислав ВолодимировичСикора, Владислав ВладимировичSikora, Vladyslav VolodymyrovychЛиндін, Микола СергійовичЛындин, Николай СергеевичLyndin, Mykola SerhiiovychГирявенко, Наталія ІванівнаГирявенко, Наталья ИвановнаHyriavenko, Nataliia IvanivnaМоскаленко, Роман АндрійовичМоскаленко, Роман АндреевичMoskalenko, Roman AndriiovychЛиндіна, Юлія МиколаївнаЛындина, Юлия НиколаевнаLyndina, Yuliia MykolaivnaСікора, Катерина ОлексіївнаСикора, Екатерина АлексеевнаSikora, Kateryna OleksiivnaЧижма, Руслана АнатоліївнаЧижма, Руслана АнатольевнаChyzhma, Ruslana AnatoliivnaДяченко, Олена ОлегівнаДяченко, Елена ОлеговнаDiachenko, Olena OlehivnaРоманюк, Анатолій МиколайовичРоманюк, Анатолий НиколаевичRomaniuk, Anatolii Mykolaiovych2021-09-202021-09-202021Sikora V., Lуndіn M., Hyriavenko N., Moskalenko R., Lуndіna Y., Sikora K., Chyzhma R., Diachenko O., Romaniuk A. Morphological peculiarities of parasitic (Trichosomoides crassicauda) infection in rat urinary bladder. Mac Vet Rev 2021; 44 (2): i-ix. https://doi.org/10.2478/macvetrev-2021-00190000-0003-4385-39030000-0002-9805-014X0000-0002-9814-65120000-0003-2560-13820000-0002-2132-09650000-0002-2342-03370000-0002-4147-6879https://essuir.sumdu.edu.ua/handle/123456789/85419Trichosomoides crassicauda (T. crassicauda) is a parasite commonly localized in the urinary bladder (UB) of laboratory and wild rats. The presence of these helminths can influence the prediction of pathological changes in the UB. Therefore, the purpose of this research was to make a comprehensive study of the features of the morphological changes in the UB wall of white laboratory rats as a result of T. crassicauda infestation. The study was performed on male rats using histological (Hematoxyline-Eosin and Alcian Blue staining) and immunohistochemical (Ki-67, Hsp70, Hsp90α, CD3 and CD20) methods. T. crassicauda was detected in both urine and UB samples. Morphological changes were observed as disruption in urothelial cell stratification and insignificant proliferative and immune responses in the UB. Increased heat shock protein levels were observed which may suggest a natural body’s resistance to this parasite.enCC BY 4.0nematodeparasiteratTrichosomoides crassicaudaurinary bladderArticle