Рябенко, Тетяна ВасилівнаRiabenko, Tetiana VasylivnaГула, Вікторія ІванівнаHula, Viktoriia IvanivnaКореньков, Олексій ВолодимировичKorenkov, Oleksii VolodymyrovychПонирко, Аліна ОлексіївнаPonyrko, Alina OleksiivnaТеслик, Тетяна ПетрівнаTeslyk, Tetiana PetrivnaДмитрук, Сергій МиколайовичDmytruk, Serhii MykolaiovychІлляшенко, Вячеслав ЮрійовичIlliashenko, Viacheslav Yu.Дудченко, Євгеній СергійовичDudchenko, Yevhenii Serhiiovych2024-05-132024-05-132023Riabenko T. V., Hula V. I., Korenkov O. V., Ponyrko A. A., Teslyk T. P. et al. Evaluation of methotrexate toxicity. Azerbaijan Medical Journal. 2023;(4).141-146. DOI: 10.34921/amj.2023.4.020.https://essuir.sumdu.edu.ua/handle/123456789/95266The article analyzes literary sources on the study of the toxic effects of methotrexate in the treatment of various diseases and examines scientific data on methods of preventing their development. According to the literary information, the main toxic effects of methotrexate manifest as damage to the liver, kidneys, bone marrow, lungs, digestive system, and skin. Methotrexate exhibits pronounced embryotoxic and teratogenic effects. Monitoring of blood test parameters and selection of an optimal dose will minimize methotrexate toxic effects and help in achieving success in the treatment.ukCC BY 4.0methotrexatetoxisityside effectsclinical evaluationbone marrow diseaseteratogenesisdigestive system diseaseembryotoxicityskin diseaselung diseaseliver diseasekidney diseaseArticle