Please use this identifier to cite or link to this item: http://essuir.sumdu.edu.ua/handle/123456789/1888
Or use following links to share this resource in social networks: Recommend this item
Title Влияние лекарственных средств с различными механизмами действия на концентрацию эпихлоргидрина в биологических средах организмав условиях острой интоксикации летучими компонентами эпоксидной смолы ЭД 20
Authors Vysotskyi, Ihor Yuriiovych  
ORCID http://orcid.org/0000-0002-6357-3362
Keywords токсокологія
токсикология
toxicology
Type Article
Date of Issue 2004
URI http://essuir.sumdu.edu.ua/handle/123456789/1888
Publisher Издательство СумГУ
License
Citation Высоцкий, И.Ю. Влияние лекарственных средств с различными механизмами действия на концентрацию эпихлоргидрина в биологических средах организмав условиях острой интоксикации летучими компонентами эпоксидной смолы ЭД 20 [Текст] / И.Ю. Высоцкий // Вісник Сумського державного університету. Серія Медицина. — 2004. — №7(66). — С. 15-24.
Abstract In the experiments on white rat-males line Wistar 150-200 gr. weight in the conditions of acute 4-hour dynamic ingalating intoxication by the flying compounds of epoxyde resine ED-20 (ER) - studied some toxicokinetics’ parameters of leader and the most toxic flying compound of ER - epichlorhydrine (ECH). For correction of ECH level in the blood serum, we used before and after intoxication quercetine (350 mg/kg), flavinate (4 mg/kg), lipine (0,8 mmol/kg), nicotinamide (260 mg/kg), acetylcysteine (450 mg/ kg) and before intoxication - inductor of epoxihydrolase omeprasole (50 mg/kg) and clofibrate (200 mg/kg). Showed that ECH is differ from very high bioaccessible long circulate in the blood serum and rich the maximum concentration on the 6-th hour after intoxication. Excretion of ECH with urine realize in comparatively low concentrations as for those which definited in the blood serum and slowly increase by the 3-d day of experiment. For decreasing degree of ECH in the blood serum - used pharmacological substances are perfomed in the next order: flavinate > omeprasole > acetylcysteine > clofibrate > quercetine > lipine > nicotinamide. Quercetine, lipine, acetylcysteine parallel to decreasing of poison containing in the blood reliable increase it’s excretion with urine. Decreasing of ECH concentration in the blood under the influence of flavinate, clofibrate, omeprasole and in a bit slighter degree - nicotinamide - followed the parallel decreasing of it’s excretion with urine, that bear about acceleration of biotransformation of poison in the body under those substances. In this work we discuss the pacularities of modificative influence used medicines on the toxicokinetics of ECH under the acute intoxication by ER. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/1888
Appears in Collections: Вісник Сумського державного університету. Медицина (2007-2013)

Views

Australia Australia
1
China China
9
France France
1
Germany Germany
499
Iran Iran
1
Ireland Ireland
768889
Lithuania Lithuania
1
Netherlands Netherlands
5
Romania Romania
1
Russia Russia
121816
Singapore Singapore
208022171
Spain Spain
1
Turkey Turkey
40
Ukraine Ukraine
17189515
United Kingdom United Kingdom
8145611
United States United States
355445777
Unknown Country Unknown Country
86

Downloads

Germany Germany
500
Ireland Ireland
768888
Kazakhstan Kazakhstan
1
Russia Russia
12
Ukraine Ukraine
17189516
United Kingdom United Kingdom
1
United States United States
208022172
Unknown Country Unknown Country
367

Files

File Size Format Downloads
2.pdf 197.56 kB Adobe PDF 225981457

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.