Please use this identifier to cite or link to this item: http://essuir.sumdu.edu.ua/handle/123456789/41947
Title: S100, bcl2 and myeloperoxid protein expirations during periodontal inflammation
Authors: Kuzenko, Yevhen Viktorovych
Romaniuk, Anatolii Mykolaiovych 
Politun, A.
Karpenko, Liudmyla Ivanivna
Keywords: S100
bcl2
MPO
Issue Year: 2015
Publisher: BMC Oral Health
Citation: Kuzenko, Y. S100, bcl2 and myeloperoxid protein expirations during periodontal inflammation [Text] / Y.Kuzenko, А. Romanyuk, A. Politun, L. Karpenko // BMC Oral Health. – 2015. - vol.15:93 - Р.1-6.
Abstract: Background:Periodontal inflammation is characterized by injuries in collagen, epithelial, bone tissues. The hypotheses to be tested were relationship between the s100, bcl2 and myeloperoxidase in gingival tissues (MPO does affect the level of s100, bcl2). The object of this study was to investigate of s100 expression, bcl2 expression and myeloperoxidase expression in periodontal inflammation. Methods:27 patients (giant-cell epulis) and 30 patients (acute and chronic inflammations) were included in the study for s100 expression, bcl2 expression and myeloperoxidase expression by immunohistochemistry and hematoxylin - eosin. Results:Giant-cells in epulis positivity for myeloperoxidase has been observed in 100 % However, only 75.31 % of giant-cells were positive for bcl2 expression. Acute 98.2 %, and chronic 89.28 % inflammation was a significant positive for myeloperoxidase. The immunohistochemical findings of s100, bcl 2 and myeloperoxidase in epithelial layers have showed the result of 100 %, 82,2 %, 100 % positive cells in acute and 100 %, 78.25 %, 100 % in chronic process of inflammation respectively. Conclusion:The results indicate that the pathogenesis of periodontal inflammation might involve inhibition of cell death, through the overexpression of bcl-2, due to identifying factors myeloperoxidase (result in the DNA damage by the product of catalysis). The highest levels of s100 activity have been found at sites with chronic inflammation.
URI: http://essuir.sumdu.edu.ua/handle/123456789/41947
Type: Article
Appears in Collections:Наукові видання (ІФСК)

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