Факультет іноземної філології та соціальних комунікацій (ІФСК)
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Item Association analysis between BGLAP rs1800247polymorphic variant and type 2 diabetes mellitus development among non-obese Ukrainians(Sumy State University, 2020) Chumachenko, Y.; Гарбузова, Вікторія Юріївна; Гарбузова, Виктория Юрьевна; Harbuzova, Viktoriia Yuriivna; Золотова, Світлана Григорівна; Золотова, Светлана Григорьевна; Zolotova, Svitlana HryhorivnaType 2 diabetes mellitus (T2DM) belongs to the diseases with hereditary predisposition, so both genetic and environmental factors influence its development. Recent studies showed, that the bone tissue regulates systemic glucose metabolism through the secretion of undercarboxylated osteocalcin (uOCN) into the systemic circulation. It is known, that uOCN binds to the GPRC6A-receptor and, therefore, stimulates insulin expression and secretion in β-cells, as well as increases muscles, liver and adipose tissue sensitivity for insulin. Thus, the thymine to cytosine transition in OCN gene (BGLAP) promoter region (rs1800247) may change the gene expression level and affect T2DM emergence. The aim of the study was to investigate the association between BGLAP rs1800247 single nucleotide polymorphism (SNP) and T2DM development among non-obese Ukrainians.