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Item The relationships of IRS-1 polymorphism with hemodynamic disorders in hypertensive patients depending on body weight and metabolic comorbidity(Aluna Publishing, 2022) Псарьова, Валентина Григорівна; Псарева, Валентина Григорьевна; Psarova, Valentyna Hryhorivna; Kochuieva, M.; Gogunska, I.; Shchur, O.; Kochuiev, G.; Tymchenko, H.The aim: The aim was to study the relationships of IRS-1 gene polymorphism with indicators of the structural and functional state of the heart and blood vessels in patients with arterial hypertension under conditions of different metabolic comorbidity and body weight. Materials and methods: We examined 340 patients with arterial hypertension with different body weight and different types of metabolic comorbidity and 30 healthy individuals aged 45-55. Anthropometric, Biochemical, Molecular genetic methods, Instrumental, Statistical methods were used. Results: The presence of G/R + R/R genotypes in hypertensive patients with normal body weight was associated with an increase in intima-media thickness (CIMT), pulse wave velocity of carotid artery (cPWV) and lower endothelium-dependent vasodilatation (EDVD) compared with G/G genotype carriers. Hypertensive patients with obesity, carriers of G/R and R/R genotypes displayed more pronounced similar changes in vascular remodeling (higher CIMT, cPWV and lower EDVD) and as well as cardiac remodeling (larger sizes and left ventricular mass (LVM)) compared with G/G genotype carriers. Overweight carriers of the G/R + R/R genotypes were characterized by enlargement of LVM and its sizes, a higher CIMT indicator, but this effect was less than in the comorbidity of hypertension and obesity. In hypertensive patients with hypertension, obesity and type 2 diabetes mellitus, the presence of G/R + R/R genotypes was associated with an increase in left ventricular size, left ventricular mass index (LVMI) and CIMT. Conclusions: The relationships of IRS-1 polymorphism with indicators of cardiovascular remodeling in hypertensive patients depending on body weight and the presence of various metabolic comorbidity have been established.Item Asthma in a patient with covid-19: does it protect or increase the risks?(Aluna Publishing, 2021) Kochuieva, М.N.; Псарьова, Валентина Григорівна; Псарева, Валентина Григорьевна; Psarova, Valentyna Hryhorivna; Shklyar, S.P.; Oparin, A.A.The aim: To investigate the impact of asthma co-morbidity on the susceptibility and clinical course of COVID-19 in asthma patients. Materials and methods: Electronic databases of Pubmed and Google Scholar were searched using keyword searches. Conclusions: Despite previous concerns about the increased risk of Covid-19 among asthmatics, most studies have not shown an increase in Covid-19 incidence among asthmatics compared to the general population. A large number of studies that have investigate the role of concomitant asthma in the susceptibility and severity of COVID-19, show conflicting results and indicate numerous factors that may affect these processes, so there is a need for large-scale studies to adjust the result to concomitant factors, which will assess the true impact of asthma on susceptibility and severity of COVID-19. Based on the recommendations of GINA 2020 regarding the management of asthma patients under Covid-19, potential protective effects of asthma therapy and the high risk of exacerbations when discontinuing basic therapy, we consider it appropriate to continue taking asthma patients therapy of asthma during a pandemic.Item Associations of IRS-1 polymorphism with various components of the metabolic syndrome in hypertensive patients(ALUNA Publishing, 2019) Kochuieva, M.; Псарьова, Валентина Григорівна; Псарева, Валентина Григорьевна; Psarova, Valentyna Hryhorivna; Ruban, L.; Кириченко, Наталія Миколаївна; Кириченко, Наталия Николаевна; Kyrychenko, Nataliia Mykolaivna; Alypova, O.; Matlai, Olha Ivanivna; Shalimova, A.; Матлай, Ольга Іванівна; Матлай, Ольга ИвановнаIntroduction: The metabolic syndrome is one of the most discussed cross-disciplinary problems of modern medicine. Now there are various definitions and criteria of diagnostics of metabolic syndrome. The abdominal obesity is considered the main component of the metabolic syndrome, as a reflection of visceral obesity which degree is offered to be estimated on an indirect indicator – a waist circumference. Alongside with abdominal obesity, a number of classifications distinguish insulin resistance (IR) as a diagnostic criterion of metabolic syndrome. It is proved that IR is one of the pathophysiological mechanisms influencing the development and the course of arterial hypertension (AH), type 2 DM and obesity. There are two components in the development of IR: genetic (hereditary) and acquired. In spite of the fact that IR has the accurate genetic predisposition, exact genetic disorders of its appearance have not been identified yet, thus demonstrating its polygenic nature. The aim: To establish possible associations of the insulin receptor substrate-1 (IRS-1) gene polymorphism with the severity of the metabolic syndrome components in patients with arterial hypertension (AH). Materials and methods: 187 patients with AH aged 45-55 years and 30 healthy individuals. Methods: anthropometry, reactive hyperemia, color Doppler mapping, biochemical blood analysis, HOMA-insulin resistance (IR), glucose tolerance test, enzyme immunoassay, molecular genetic method. Results: Among hypertensive patients, 103 had abdominal obesity, 43 - type 2 diabetes, 131 - increased blood triglycerides, 19 - decreased high density lipoproteins, 59 - prediabetes (33 - fasting hyperglycemia and 26 - impaired glucose tolerance), 126 had IR. At the same time, hypertensive patients had the following distribution of IRS-1 genotypes: Gly/Gly - 47.9%, Gly/Arg - 42.2% and Arg/Arg - 10.7%, whereas in healthy individuals the distribution of genotypes was significantly different: Gly/Gly - 86.8% (p<0.01), Gly/ Arg - 9.9% (p<0.01) and Arg/Arg - 3.3% (p<0.05). Hypertensive patients with Arg/Arg and Gly/Arg genotypes had significantly higher HOMA-IR (p<0.01), glucose, insulin and triglycerides levels (p<0.05), than in Gly/Gly genotype. At the same time, body mass index, waist circumference, blood pressure, adiponectin, HDL, interleukin-6, C-reactive protein, degree of endothelium-dependent vasodilation, as well as the frequency of occurrence of impaired glucose tolerance did not significantly differ in IRS-1 genotypes. Conclusions: in hypertensive patients, the genetic polymorphism of IRS-1 gene is associated with such components of the metabolic syndrome as hypertriglyceridemia and fasting hyperglycemia; it is not associated with proinflammatory state, endothelial dysfunction, dysglycemia, an increase in waist circumference and decrease in HDL.