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Item A case of hidden myocardial infarction by atrial fibrillation against the background of diabetes mellitus and arterial hyper- tension(Elm, Azerbaijan, 2023) Сміян, Олександр Іванович; Smiian, Oleksandr Ivanovych; Романюк, Софія Анатоліївна; Romaniuk, Sofiia Anatoliivna; Приступа, Людмила Никодимівна; Prystupa, Liudmyla Nykodymivna; Романюк, Оксана Костянтинівна; Romaniuk, Oksana Kostiantynivna; Avuax, E.V.; Abdul-Rahman, T.; Boyagina, O.D.; Кузенко, Євген Вікторович; Kuzenko, Yevhen Viktorovych; Denisenko, B.S.; Романюк, Анатолій Миколайович; Romaniuk, Anatolii MykolaiovychThis article presents information about acute subendocardial myocardial infarction of the posterior wall of the left ventricle, which developed against the background of type 2 diabetes mellitus and arterial hyper- tension. The only clinical symptom of critical heart disease was a tachysystolic form of permanent atrial fi- brillation. Despite a complex of therapeutic manipulations, the patient died. The final diagnosis of acute subendocardial myocardial infarction of the posterior wall of the left ventricle was established only after autopsy. The presented clinical case demonstrates an atypical course of myocardial infarction manifested by latent atrial fibrillation. This case focuses on the need for a comprehensive examination of patients with atrial fi- brillation and the exclusion, first of all, of irreversible myocardial damage.Item Clinical features and nature of acute bronchitis in preschool children in combination with and without euthyroid sick syndrome(МедЕксперт, 2021) Гавриленко, Анастасія Олександрівна; Гавриленко, Анастасия Александровна; Havrylenko, Anastasiia Oleksandrivna; Сміян, Олександр Іванович; Смиян, Александр Иванович; Smiian, Oleksandr Ivanovych; Moschich, O.P.; Reznychenko, Yu.G.; Васильєва, Олена Геннадіївна; Васильева, Елена Геннадьевна; Vasylieva, Olena Hennadiivna; Сміян, Катерина Олександрівна; Смиян, Екатерина Александровна; Smiian, Kateryna Oleksandrivna; Романюк, Оксана Костянтинівна; Романюк, Оксана Константиновна; Romaniuk, Oksana Kostiantynivna; Манько, Юлія Анатоліївна; Манько, Юлия Анатолиевна; Manko, Yuliia Anatoliivna; Syadrista, Yu.O.Acute bronchitis is a common disease in children. During inflammation, including the respiratory tract, the pituitary gland and thyroid gland are involved in the process, on the response of which the body's protective and adaptive stability depends. Therefore, the adequacy of the functioning of these organs depends on the nature of the course of acute infectious diseases, including acute bronchitis. Thus, children with this disease often develop a euthyroid sick syndrome, which manifests itself most often in the form of «low T3 syndrome». Purpose — to study the clinical features of acute bronchitis in preschool children in combination with euthyroid sick syndrome and without it. Materials and methods. 135 children of preschool age (from 3 to 6 years), patients with acute bronchitis (main group) and 28 healthy children (control group) were examined. All patients in the main group were divided into two. The first group consisted of children with acute bronchitis (92 children), and the second group — patients with acute bronchitis in combination with euthyroid sick syndrome (43 children). Clinical and anamnestic (collection of complaints, anamnesis of disease and life, physical examination) research methods were used. Results. It was found that in patients with acute bronchitis with signs of euthyroid sick syndrome, a greater number of cases of prolonged neonatal jaundice, perinatal CNS lesions and births weighing less than 2800 g were found. The leading clinical syndromes in patients with acute bronchitis were intoxication, catarrhal and hyperthermic. General weakness was the main symptom of intoxication syndrome in children with acute bronchitis without signs of euthyroid syndrome, while anxiety was more common in children of group II. The main symptom of catarrhal syndrome was a daytime dry cough. Hyperthermic syndrome was significantly more common with fever. Hectic body temperature was found in most children with acute bronchitis in combination with euthyroid sick syndrome than without it. Children who showed signs of euthyroid sick syndrome were ill for longer. Conclusions. Patients with acute bronchitis combined with euthyroid sick syndrome generally have a more severe history of life and disease, more severe acute bronchitis than patients without abnormalities in hormonal status. The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local ethics committee of all participating institutions. The informed consent of the patient was obtained for conducting the studies.Item Adaptive alterations of pinealocytes after the long-term influence of heavy metal salts on the body(Springer, 2020) Гринцова, Наталія Борисівна; Гринцова, Наталия Борисовна; Hryntsova, Nataliia Borysivna; Timakova, O.; Романюк, Оксана Костянтинівна; Романюк, Оксана Константиновна; Romaniuk, Oksana Kostiantynivna; Tymchenko, Z.; Коробчанська, Анна Борисівна; Коробчанская, Анна Борисовна; Korobchanska, Anna Borysivna; Романюк, Анатолій Миколайович; Романюк, Анатолий Николаевич; Romaniuk, Anatolii MykolaiovychEpiphysis and parathyroid glands take part in the regulation of the adaptive capacity of the body. The aim was to study of morphological and immunohistochemical features of epiphysis's pinealocytes and parathyroid cells under heavy metal salts influence.Item Prognostic role of ER, PR, HER-2/neu expression in the fallopian tubes’ cancer(Springer, 2017) Романюк, Анатолій Миколайович; Романюк, Анатолий Николаевич; Romaniuk, Anatolii Mykolaiovych; Гирявенко, Наталія Іванівна; Гирявенко, Наталья Ивановна; Hyriavenko, Nataliia Ivanivna; Линдін, Микола Сергійович; Лындин, Николай Сергеевич; Lyndin, Mykola Serhiiovych; Романюк, Оксана Костянтинівна; Романюк, Оксана Константиновна; Romaniuk, Oksana Kostiantynivna; Коробчанська, Анна Борисівна; Коробчанская, Анна Борисовна; Korobchanska, Anna BorysivnaObjective: The aim of this study was to investigate of steroid receptors expression and the HER-2/neu oncoprotein in the tissue of the fallopian tubes’ cancer.Item The features of p53 and Ki-67 expression during Gleason's grade increase in prostate cancer(Springer, 2019) Линдін, Микола Сергійович; Лындин, Николай Сергеевич; Lyndin, Mykola Serhiiovych; Піддубний, Артем Михайлович; Поддубный, Артем Михайлович; Piddubnyi, Artem Mykhailovych; Сікора, Владислав Володимирович; Сикора, Владислав Владимирович; Sikora, Vladyslav Volodymyrovych; Романюк, Оксана Костянтинівна; Романюк, Оксана Константиновна; Romaniuk, Oksana Kostiantynivna; Kravtsova, Olha Ivanivna; Романюк, Анатолій Миколайович; Романюк, Анатолий Николаевич; Romaniuk, Anatolii Mykolaiovych; Кравцова, Ольга Іванівна; Кравцова, Ольга ИвановнаBackground & Objectives: Prostate cancer is the most common malignant tumour of the male reproductive organs. Its course depends on the histological and immunohistochemical characteristics of neoplasias. In view of this, the purpose of study was to investigate the influences of prostate cancer differentiation on peculiarities of Ki-67 and p53 expression.Item Features of the hidden immunodeficiency in a newborn baby whose mother suffered from leukemia(Springer, 2018) Сікора, Владислав Володимирович; Сикора, Владислав Владимирович; Sikora, Vladyslav Volodymyrovych; Романюк, Анатолій Миколайович; Романюк, Анатолий Николаевич; Romaniuk, Anatolii Mykolaiovych; Линдін, Микола Сергійович; Лындин, Николай Сергеевич; Lyndin, Mykola Serhiiovych; Сміян, Олександр Іванович; Смиян, Александр Иванович; Smiian, Oleksandr Ivanovych; Романюк, Оксана Костянтинівна; Романюк, Оксана Константиновна; Romaniuk, Oksana Kostiantynivna; Москаленко, Роман Андрійович; Москаленко, Роман Андреевич; Moskalenko, Roman Andriiovych; Гирявенко, Наталія Іванівна; Гирявенко, Наталья Ивановна; Hyriavenko, Nataliia Ivanivna; Карпенко, Людмила Іванівна; Карпенко, Людмила Ивановна; Karpenko, Liudmyla IvanivnaBackground & Objective: To study the features of the pathomorphological changes in the intestines, spleen and thymus gland in a baby with the hidden congenital immunodeficiency provoked by the BCG vaccination. Method: We present a case of the death of the newborn baby (14 days of life), whose mother suffered from acute leukemia in youth. The baby was born without pathologies. Therefore, she was vaccinated against hepatitis B (Engerix-B) and tuberculosis (BCG) according to the immunizations schedule. In a week the state of health of the baby became worse, the disease progressed despite the pharmacological treatment and led to multiple organ failures that caused the death. During the postmortem examination the changes in the intestines, spleen and thymus gland were observed and were studied in detail by using the histologicalimmunohistological (CD3/CD79α/CK-pan) methods.Results: The histological study of the intestines revealed the diffuse foci of necrosis, strong leukocyte infiltration and vascular congestion with multiple hemorrhages. Perivascular T-cells hypoplasia was observed in the spleen. Thymus lobules were reduced, cortex thickness (lymphocyte loss and reticular stroma collapse) and proliferation of the epithelial reticular cells were observed. Numerous Hassall's corpuscles, different in their size, were observed. The results of the immunohistochemical study of the spleen showed the absence of the perivascular T-cells and the follicular hyperplasia of B-lymphocytes at the same time. Small number of CD3/CD79a-positive cells was observed in the thymus gland, CK-pan - significantly expressed in epithelial-reticular cells. The abovementioned changes indicate the development of the congenital T-cells immunodeficiency that led to the ulcerous-necrotic enterocolitis. Conclusion: This clinical case demonstrates the importance of early diagnosis of immune status in the newborns, whose parents have leukemia in anamnesis. BCG-vaccination against the background of T-cell immunodeficiency may lead to the dangerous complications that threaten baby’s life.Item The case of undiagnosed immunodeficiency in child from mother with leukemia anamnesis(Interventional Medicine & Applied Science, 2018) Сміян, Олександр Іванович; Смиян, Александр Иванович; Smiian, Oleksandr Ivanovych; Линдін, Микола Сергійович; Лындин, Николай Сергеевич; Lyndin, Mykola Serhiiovych; Романюк, Оксана Костянтинівна; Романюк, Оксана Константиновна; Romaniuk, Oksana Kostiantynivna; Сікора, Владислав Володимирович; Сикора, Владислав Владимирович; Sikora, Vladyslav Volodymyrovych; Піддубний, Артем Михайлович; Поддубный, Артем Михайлович; Piddubnyi, Artem Mykhailovych; Юрченко, Алла Владиславівна; Юрченко, Алла Владиславовна; Yurchenko, Alla Vladyslavivna; Коробчанська, Анна Борисівна; Коробчанская, Анна Борисовна; Korobchanska, Anna Borysivna; Тарасова, Ірина Віталіївна; Тарасова, Ирина Витальевна; Tarasova, Iryna Vitaliivna; Гирявенко, Наталія Іванівна; Гирявенко, Наталья Ивановна; Hyriavenko, Nataliia Ivanivna; Сікора, Катерина Олексіївна; Сикора, Екатерина Алексеевна; Sikora, Kateryna Oleksiivna; Романюк, Анатолій Миколайович; Романюк, Анатолий Николаевич; Romaniuk, Anatolii MykolaiovychAcute lymphoblastic leukemia (ALL) in pregnant women is rare experience, but it can complicate the gestation by increasing the risk of miscarriage and premature birth. However, the adequate carrying of the pregnancy is possible for women who suffered from leukemia in childhood and achieved the remission during the treatment. Furthermore, there are some facts about the possibility of immunosuppression in children whose parents suffer from various immunodeficiency disorders, including ALL. This clinical case demonstrates the importance of correct diagnostics in order to reveal the congenital pathologies of the immune system in children, whose parents suffered from lymphocytic leukemia, even in case of full clinical and laboratory remission for a significant period of time. In the hospital, the thread metric approach was used for sepsis diagnostics. Conducted treatment was ineffective due to the inadequate immune response in the child and lack of the targeted adjusted measures to immunodeficiency disorder. The present case demonstrates the congenital T-cells immunodeficiency in a child who was complicated by the development of acute ulceronecrotic enterocolitis after vaccination. The treatment that was targeted mainly at the agent eradication did not give the desired results due to non-responsiveness of the immune system of the child.Item The influence of atopic dermatitis on the quality of life of children(Sumy State University, 2016) Slobodjan, G.; Romaniuk, Oksana Kostiantynivna; Романюк, Оксана Костянтинівна; Романюк, Оксана КонстантиновнаThe aim: to analyze psychosocial aspects based on a comprehensive assessment of determine the quality of life parameters in families where a child suffers from atopic dermatitis. Materials and Methods. The study involved 62 families in which a child suffers from atopic dermatitis. The diagnosis of AD is installed in accordance of the classification and diagnostic criteria, according to the Protocol of diagnosis and treatment of atopic dermatitis in children №767 Ministry of Health of Ukraine.Item Structural changes in osseous and cartilaginous tussues of the mandible under effects of heavy metals salts on the body(Inter Ging, 2016) Романюк, Анатолій Миколайович; Романюк, Анатолий Николаевич; Romaniuk, Anatolii Mykolaiovych; Korobchanska, A.B.; Линдін, Микола Сергійович; Лындин, Николай Сергеевич; Lyndin, Mykola Serhiiovych; Романюк, Оксана Костянтинівна; Романюк, Оксана Константиновна; Romaniuk, Oksana Kostiantynivna; Сміянов, Євген Владиславович; Смиянов, Евгений Владиславович; Smiianov, Yevhen Vladyslavovych; Сауляк, Сергій Володимирович; Сауляк, Сергей Владимирович; Sauliak, Serhii Volodymyrovych; Романюк, Софія Анатоліївна; Романюк, София Анатольевна; Romaniuk, Sofiia Anatoliivna; Slobodian, H.We have studied morphological changes in the osseous and cartilaginous tissue of the lower jaw of 72 experimental male albino rats whose bodies were influenced by the salts of heavy metals. We used anatomical, osteometric, spectrophotometric, histological, histochemical, morphometric, immunomorphological and statistical methods. It is shown that heavy metals salts cause the development of deep and persistent structural changes in the osseous and cartilaginous tissues of the mandible, which is accompanied by inhibition of growth, development of resorptive processes in the osseous tissue, reduced mineralization, depletion of inorganic matrix in macroand microelements. Negative morphological changes develop in the process cartilage: zonal structure is impaired, proliferative activity of chondrocytes is inhibited.Item Morphogenetic biomineralization aspects in the human heart valve affected by atherosclerosis(Springer, 2012) Романюк, Анатолій Миколайович; Романюк, Анатолий Николаевич; Romaniuk, Anatolii Mykolaiovych; Москаленко, Роман Андрійович; Москаленко, Роман Андреевич; Moskalenko, Roman Andriiovych; Данильченко, Сергій Миколайович; Данильченко, Сергей Николаевич; Danylchenko, Serhii Mykolaiovych; Романюк, Оксана Костянтинівна; Романюк, Оксана Константиновна; Romaniuk, Oksana Kostiantynivna; Москаленко, Юлія Василівна; Москаленко, Юлия Васильевна; Moskalenko, Yuliia Vasylivna; Романюк, Софія Анатоліївна; Романюк, София Анатольевна; Romaniuk, Sofiia AnatoliivnaДослідження мінеральних патологічних утворень на серцевих клапанах людини комплексом морфологічних та фізико-хімічних методів показало, що вони являють собою агрегати зі взаємодіючої органічної і мінеральної складових, співвідношення яких змінюється по мірі «дозрівання»: органічний компонент зменшується, а мінеральний компонент, представлений карбонатвмісним гідроксиапатитом з домішками хлору, росте і при цьому вдосконалюється, тобто процес має динамічний характер. При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/29255