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Item Correction of myocardial changes on an animal experimental model with meldonim(Oxford University Press, 2022) Ярмоленкo, Ольга Сергіївна; Yarmolenkо, Olha Serhiivna; Бумейстер, Валентина Іванівна; Bumeister, Valentyna Ivanivna; Приходько, Ольга Олексіївна; Prykhodko, Olha Oleksiivna; Гордієнко, Олена Володимирівна; Hordiienko, Olena Volodymyrivna; Деміхова, Надія Володимирівна; Demikhova, Nadiia VolodymyrivnaThe aim of our study was the determination of morphological changes in the myocardium of old laboratory animals under the influence of severe hypoosmolar hyperhydration and attempt to correct the identified changes by means of meldonium.Item Monitoring of macroelement composition of rats' organs and tissues in norm and under the influences of the lithium salts(УкрНДІ медицини транспорту, 2019) Ілляшенко, Вячеслав Юрійович; Illiashenko, Viacheslav Yuriiovych; Deineko, O.S.; Ткач, Геннадій Федорович; Tkach, Hennadii Fedorovych; Максимова, Олена Сергіївна; Maksymova, Olena Serhiivna; Сікора, Віталій Зіновійович; Sikora, Vitalii Zinoviiovych; Бумейстер, Валентина Іванівна; Bumeister, Valentyna IvanivnaLithium - is a vital microelement with a wide range of biological and medical effects (Robert L. Findling, 2019; Somayeh Moradi, 2019; Dania Shakaroun, 2019). It has a physiological effect if the concentration in the blood plasma from 0,14 to 1,4 mmol/L and pharmacological effect if the concentration more than 1 mmol/L. If the concentration of lithium more than 2 mmol/L the toxic effect is present, so its content in the body should monitored at the lithium therapy (Anatoly V. Skalny, 2004). Autonomous power sources based on lithium has become widespread in home use and industries (Mahmut Dirican, 2019). In the absence of recycle of lithium batteries, lithium-contaminated drinking water and food can become sources of uncontrolled lithium intake.Item Анатомія людини(Сумський державний університет, 2024) Бумейстер, Валентина Іванівна; Bumeister, Valentyna Ivanivna; Сікора, Віталій Зіновійович; Sikora, Vitalii Zinoviiovych; Сулим, Людмила Григорівна; Sulym, Liudmyla Hryhorivna; Приходько, Ольга Олексіївна; Prykhodko, Olha Oleksiivna; Гордієнко, Олена Володимирівна; Hordiienko, Olena Volodymyrivna; Ярмоленкo, Ольга Сергіївна; Yarmolenkо, Olha Serhiivna; Дмитрук, Сергій Миколайович; Dmytruk, Serhii Mykolaiovych; Теслик, Тетяна Петрівна; Teslyk, Tetiana Petrivna; Дудченко, Євгеній Сергійович; Dudchenko, Yevhenii Serhiiovych; Понирко, Аліна Олексіївна; Ponyrko, Alina Oleksiivna; Рябенко, Тетяна Василівна; Riabenko, Tetiana Vasylivna; Ілляшенко, Вячеслав Юрійович; Illiashenko, Viacheslav YuriiovychНавчальний посібник містить стислий матеріал про будову тіла людини, що дасть можливість вивчити основні аспекти складових людського організму, їхні функціональні можливості, а для лікарів-практиків – повторити необхідні в практичній медицині знання з анатомії людини.Item Markers of cardiovascular complications in patients with type 2 diabetes mellitus and arterial hypertension(Bangladesh Journal of Medical Science, 2018) Деміхова, Надія Володимирівна; Demikhova, Nadiia Volodymyrivna; Чернацька, Ольга Миколаївна; Chernatska, Olha Mykolaivna; Мазур, Тетяна Станіславівна; Mazur, Tetiana Stanislavivna; Бокова, Світлана Іванівна; Bokova, Svitlana Ivanivna; Руденко, Тетяна Миколаївна; Rudenko, Tetiana Mykolaivna; Бумейстер, Валентина Іванівна; Bumeister, Valentyna Ivanivna; Demikhov, O.I.; Деміхов, О.І.Hypertensive patients with type 2 diabetes mellitus are also at increased risk for diabetes mellitus–specific complications, including nephropathy. Even the smallest degree of albuminuria increases risk for cardiovascular diseases and all-cause death. The common conditions coexisting with type 2 diabetes (e.g., hypertension and dyslipidemia) are clear risk factors for cardiovascular diseases.Item The effect of the experimental chronic hyperglycemia on the kidney and myocardium(ДУ "Інститут нефрології Національної академії медичних наук України", 2021) Yarmolenkо, Olha Serhiivna; Ярмоленкo, Ольга Сергіївна; Bumeister, Valentyna Ivanivna; Бумейстер, Валентина Іванівна; Polak,S.; Hordiienko, Olena Volodymyrivna; Гордієнко, Олена Володимирівна; Prykhodko, Olha Oleksiivna; Приходько, Ольга Олексіївна; Demikhova, Nadiia Volodymyrivna; Деміхова, Надія Володимирівна; Shkatula, Yurii Vasylovych; Шкатула, Юрій Васильович; Demikhov, Andrii Oleksiiovych; Деміхов, Андрій ОлексійовичThe number of patients with diabetes increases annually. Modern forecasts predict that diabetes will be the seventh leading cause of death in 2030. Despite many significant advances in the research of diabetes and the use of new modern treatments, the disease is still progressing, and it is necessary to continue to study the effects of diabetes on human systems and organs: kidney and myocardium.Item The Remodeling of Lungs Under the Influence of Alloxan-Induced Hyperglycemia("Carol Davilla" University of Medicine and Pharmacy, 2020) Теслик, Тетяна Петрівна; Teslyk, Tetiana Petrivna; Ярмоленкo, Ольга Сергіївна; Yarmolenkо, Olha Serhiivna; Бумейстер, Валентина Іванівна; Bumeister, Valentyna Ivanivna; Деміхова, Надія Володимирівна; Demikhova, Nadiia Volodymyrivna; Приходько, Ольга Олексіївна; Prykhodko, Olha Oleksiivna; Дмитрук, Сергій Миколайович; Dmytruk, Serhii Mykolaiovych; Dehtyarova, І.Diabetes mellitus is a global medical and social problem. 2-3% of the population suffers from diabetes mellitus. According to current forecasts, the number of people with diabetes mellitus will double every 15 years. Diabetes mellitus is the basis for the development of complex comorbidities and complications such as diabetic microangiopathy and neuropathy. Diabetes patients are at increased risk for atherosclerosis, coronary heart disease, and renal failure. Scientists around the world have been thoroughly engaged in the problem of hyperglycemia, which is the consequence of type 1 diabetes mellitus, but the causes of its occurrence have not been fully established yet. The study aimed to investigate the lungs of pre-reproductive age rats under the influence of alloxan-induced hyperglycemia.Item The remodeling of lungs under the influence of alloxan-induced hyperglycemia(Sanatatea Press Group on behalf of the Romanian Society of Diabetes Nutrition and Metabolic Diseases, 2020) Теслик, Тетяна Петрівна; Teslyk, Tetiana Petrivna; Ярмоленкo, Ольга Сергіївна; Yarmolenkо, Olha Serhiivna; Бумейстер, Валентина Іванівна; Bumeister, Valentyna Ivanivna; Деміхова, Надія Володимирівна; Demikhova, Nadiia Volodymyrivna; Приходько, Ольга Олексіївна; Prykhodko, Olha Oleksiivna; Дмитрук, Сергій Миколайович; Dmytruk, Serhii Mykolaiovych; Dehtyarova, I.Introduction: Diabetes mellitus is a global medical and social problem. 2-3% of the population suffers from diabetes mellitus. According to current forecasts, the number of people with diabetes mellitus will double every 15 years. Diabetes mellitus is the basis for the development of complex comorbidities and complications such as diabetic microangiopathy and neuropathy. Diabetes patients are at increased risk for atherosclerosis, coronary heart disease, and renal failure. Scientists around the world have been thoroughly engaged in the problem of hyperglycemia, which is the consequence of type 1 diabetes mellitus, but the causes of its occurrence have not been fully established yet. The study aimed to investigate the lungs of pre-reproductive age rats under the influence of alloxan-induced hyperglycemia. Material and Methods: 12 rats of 3 months of age were involved in the experiment. They were divided into two series: experimental and control. The Control series includes six intact rats. For the experimental modeling of hyperglycemia, we used alloxan monohydrate, pre-dissolved in 0.9% solution of sodium chloride, which was then injected intraperitoneally once at a dose of 20 mg/100 g on an empty stomach. The experiment lasted 60 days. We measured the glucose level using the Accu-Chek Advantage (Boehringer, Germany) at2, 12, and 24 hours after alloxan injection, and then weekly. The average level of glucose in the blood remained at 11 mmol/L ± 2 mmol/L. To study the remodeling of the lungs, we used the histological examination by a light microscope (Olympus BH-2) and histomorphometry using the universal certified program “SEO Scan Lab 2.0” and “SEO Image Lab 2.0”. The obtained data were processed on a personal computer using the software “GraphPad” and a licensed Excel XP spreadsheet editor (Microsoft Office 2013). The data were analyzed by unpaired t-test. P values ≤0.05 were considered as statistically significant. Results: Obtained morphometric data shows the increase of the width of alveoli by 8.5% (p < 0.05), the width of the conducting part of the respiratory bronchiole by 15.7 % (p < 0.05) and the thickness of the interalveolar septum by 8.3% (p < 0.05). The wall thickness of pulmonary vessels increased by 22.9% (p <0.05). Lymphoid nodules were more hypertrophied compared to the control ones by 2.4 times (p <0.05). Conclusions: Alloxan-induced hyperglycemia leads to the development of emphysematous changes in combination with restriction. The vascular wall of muscular pulmonary vessels was thickened due to hypertrophy of the tunica media and tunica externa. The hypertrophy of lymphoid follicles and lymph nodes of the upper and lower mediastinum was observed in experimental animals.Item Correction of myocardial changes on an animal experimental model with meldonim(Oxford University Press, 2022) Ярмоленкo, Ольга Сергіївна; Ярмоленко, Ольга Сергеевна; Yarmolenkо, Olha Serhiivna; Бумейстер, Валентина Іванівна; Бумейстер, Валентина Ивановна; Bumeister, Valentyna Ivanivna; Приходько, Ольга Олексіївна; Prykhodko, Olha Oleksiivna; Гордієнко, Олена Володимирівна; Гордиенко, Елена Владимировна; Hordiienko, Olena Volodymyrivna; Деміхова, Надія Володимирівна; Демихова, Надежда Владимировна; Demikhova, Nadiia VolodymyrivnaProlonged hypoosmolar overhydration causes a volume overload necessitating cardioprotectors together with a complex of measures aimed at stabilizing the water and electrolyte balance. The content of water and electrolytes in the human body changes throughout life, so the body's response to the disorder of water and salt balance may be different depending on age. The fluid overload positively correlates with adverse outcomes in critically ill patients. One of the main tasks of modern cardiology is to find the means of leveling the influence of adverse factors on myocardium in different aged patients. The aim of our study was the determination of morphological changes in the myocardium of old laboratory animals under the influence of severe hypoosmolar hyperhydration and attempt to correct the identified changes by means of meldonium.Item Features of morphological rearrangements of structural components in the rat pineal gland under the impact of heavy metal salts(State Institution “V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", 2021) Гринцова, Наталія Борисівна; Гринцова, Наталия Борисовна; Hryntsova, Nataliia Borysivna; Романюк, Анатолій Миколайович; Романюк, Анатолий Николаевич; Romaniuk, Anatolii Mykolaiovych; Hodorova, I.; Карпенко, Людмила Іванівна; Карпенко, Людмила Ивановна; Karpenko, Liudmyla Ivanivna; Бумейстер, Валентина Іванівна; Бумейстер, Валентина Ивановна; Bumeister, Valentyna Ivanivna; Дмитрук, Сергій Миколайович; Дмитрук, Сергей Николаевич; Dmytruk, Serhii Mykolaiovych; Зайцева, Станіслава Станіславівна; Зайцева, Станислава Станиславовна; Zaitseva, Stanislava StanislavivnaThe development of the pathology of individual organs and systems undoubtedly depends on adverse envi-ronmental factors. Particular attention of researchers attracts heavy metal salts. Epiphyseal hormones play a key role in regulating and maintaining basic body functions. The study was to elucidate the morphological and morphometric rearrangements the structural components changes in the pineal gland of mature rats under the influence of heavy metal salts. Materials and methods. The experiment was performed on 12 white mature male rats weighing 200–250 g at the age of 7–8 months, which were divided into 2 groups (group 1 control and group 1 experi-mental). Animals of the experimental group were simulated microelementosis by adding to drinking water a mixture of heavy metal salts for 30 days: zinc (ZnSO4 7H2O) — 5 mg/L, copper (CuSO4 5H2O) — 1 mg/L, iron (FeSO4) — 10 mg/L, manganese (MnSO4 5H2O) — 0.1 mg/L, lead (Pb(NO3)2) — 0.1 mg/L, and chromium (K2Cr2O7) — 0.1 mg/L. General morphological and statistical research methods were used (histological, morpho-metric and variational statistics methods). Results. The 30-days impact of the heavy metal salts combination on the rat body caused in the pineal gland morphological changes of nonspecific polymorphic nature, which were expressed in the increased vascular area, active glial response, hypertrophy of pinealocyte nuclei and increase of their optical density. Cytological signs in most pinealocytes indicated the predominance of indolamine synthesis over polypeptides. The main pathogenetic mechanisms of the influence of heavy metal salts on the organ have been established: change in the vascular lumen area, blood rheological properties impairment, tissue hypoxia, nucleus hypertrophy and change in their optical density. Conclusions.Morphological changes in the gland comply with the stress phase of the general adaptation syndrome. The above morphological changes negatively affected the processes of hormones evacuation into the blood, the course of the general adaptation syndrome and the homeostasis restoration in the organ.Item The effect of the experimental chronic hyperglycemia on the kidney and myocardium(State Institution «Institute of Nephrology NAMS of Ukraine", 2021) Ярмоленкo, Ольга Сергіївна; Ярмоленко, Ольга Сергеевна; Yarmolenkо, Olha Serhiivna; Бумейстер, Валентина Іванівна; Бумейстер, Валентина Ивановна; Bumeister, Valentyna Ivanivna; Polak, S.; Гордієнко, Олена Володимирівна; Гордиенко, Елена Владимировна; Hordiienko, Olena Volodymyrivna; Приходько, Ольга Олексіївна; Prykhodko, Olha Oleksiivna; Деміхова, Надія Володимирівна; Демихова, Надежда Владимировна; Demikhova, Nadiia Volodymyrivna; Шкатула, Юрій Васильович; Шкатула, Юрий Васильевич; Shkatula, Yurii Vasylovych; Деміхов, Олексій Ігорович; Демихов, Алексей Игоревич; Demikhov, Oleksii Ihorovychhe number of patients with diabetes increases annually. Modern forecasts predict that diabetes will be the seventh leading cause of death in 2030. Despite many significant advances in the research of diabetes and the use of new modern treatments, the disease is still progressing, and it is necessary to continue to study the effects of diabetes on human systems and organs: kidney and myocardium.Methods. A total of 24 rats of reproductive age (6 months old) were involved in this experimental study. Experimental rats were injected with alloxan intraperitoneally once at a dose of 20 mg/100 g on an empty stomach. In addition, they received a 10% glucose solution 24 hours after alloxan injection and a 5% glucose solution during the experiment. We measured glucose level with Accu-Chek Advantage (Boehringer, Germany) after 2, 12, and 24 hours after alloxan injection, and then weekly. The subjects of the investigation were kidney and heart of the experimental (n=12) and control (n=12) animals for correct comparative analysis.Results. The average blood glucose level remained at 11 mmol/L ± 2 mmol/L. During the experimental period, the rats’ weight gain, dilation of both ventricles and relative renal weight gain were determined. By the histological examination of the myocardium, we revealed polymorphic nuclei, perinuclear cytolysis, fragmentation, wavy-like deformation of cardiomyocytes, stromal and perivascular edema, uneven filling of blood vessels, and local fibrosis. Thinning of fibrous capsule and cortical layer, destruction of nephrons, and hemorrhages were detected in the kidney. Conclusions. Our study confirms the robustness of alloxan-induced hyperglycemia in rats. We came to this conclusion because the early changes in the kidneys and heart are explained by the development of microangiopathies, which is a typical feature of the pathogenesis of diabetes. With prolonged exposure to chronic hyperglycemia, structural disorders of vital organs are worsened. This experimental model could be used for conducting comprehensive research aimed to study the mechanisms of diabetes mellitus, the effects of hyperglycemia on organs and tissues, and correct the complications.