Видання зареєстровані авторами шляхом самоархівування
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Item Effects of the sources of calcium and phosphorus on the structural and functional properties of ceramic coatings on titanium dental implants produced by plasma electrolytic oxidation(Elsevier, 2021) Кириленко, Сергій Дмитрович; Kyrylenko, Serhii Dmytrovych; Warchoł, F.; Олешко, Олександр Миколайович; Oleshko, Oleksandr Mykolaiovych; Гусак, Євгенія Володимирівна; Husak, Yevheniia Volodymyrivna; Kazek-Kęsik, A.; Корнiєнко, Вiкторiя Володимирiвна; Korniienko, Viktoriia Volodymyrivna; Дейнека, Володимир Миколайович; Deineka, Volodymyr Mykolaiovych; Sowa, M.; Maciej, A.; Michalska, J.; Jakóbik-Kolon, A.; Matuła, I.; Basiaga, M.; Голубнича, Вікторія Миколаївна; Holubnycha, Viktoriia Mykolaivna; Stolarczyk, A.; Pisarek, M.; Mishchenko, O.; Погорєлов, Максим Володимирович; Pohorielov, Maksym Volodymyrovych; Simka, W.Plasma Electrolytic Oxidation (PEO) is as a promising technique to modify metal surfaces by application of oxide ceramic coatings with appropriate physical, chemical and biological characteristics. Therefore, objective of this research was to find the simplest settings, yet able to produce relevant bioactive implant surfaces layers on Ti implants by means of PEO. We show that an electrolyte containing potassium dihydrogen phosphate as a source of P and either calcium hydroxide or calcium formate as a source of Ca in combination with a chelating agent, ethylenediamine tetraacetic acid (EDTA), is suitable for PEO to deliver coatings with desired properties. We determined surface morphology, roughness, wettability, chemical and phase composition of titanium after the PEO process. To investigate biocompatibility and bacterial properties of the PEO oxide coatings we used microbial and cell culture tests. The electrolyte based on Ca(OH)2 and EDTA promotes active crystallization of apatites after PEO processing of the Ti implants. The PEO layers can increase electrochemical corrosion resistance. The PEO can be potentially used for development of bioactive surfaces with increased support of eukaryotic cells while inhibiting attachment and growth of bacteria without use of antibacterial agents.Item Synthetic Calcium–Phosphate Materials for Bone Grafting(MDPI Open Access Publishing, 2023) Mishchenko, O.; Яновська, Ганна Олександрівна; Yanovska, Hanna Oleksandrivna; Kosinov, O.; Maksymov, D.; Москаленко, Роман Андрійович; Moskalenko, Roman Andriiovych; Ramanavicius, A.; Погорєлов, Максим Володимирович; Pohorielov, Maksym VolodymyrovychSynthetic bone grafting materials play a significant role in various medical applications involving bone regeneration and repair. Their ability to mimic the properties of natural bone and promote the healing process has contributed to their growing relevance. While calcium–phosphates and their composites with various polymers and biopolymers are widely used in clinical and experimental research, the diverse range of available polymer-based materials poses challenges in selecting the most suitable grafts for successful bone repair. This review aims to address the fundamental issues of bone biology and regeneration while providing a clear perspective on the principles guiding the development of synthetic materials. In this study, we delve into the basic principles underlying the creation of synthetic bone composites and explore the mechanisms of formation for biologically important complexes and structures associated with the various constituent parts of these materials. Additionally, we offer comprehensive information on the application of biologically active substances to enhance the properties and bioactivity of synthetic bone grafting materials. By presenting these insights, our review enables a deeper understanding of the regeneration processes facilitated by the application of synthetic bone composites.