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    The relationship between lipid metabolism and the level of albuminuria with single nucleotide polymorphism - 204a>c [rs 3808607] cyp7a1 gene in patients with type 2 diabetes mellitus and diabetic nephropathy
    (Romanian National University, 2019) Деміхова, Надія Володимирівна; Демихова, Надежда Владимировна; Demikhova, Nadiia Volodymyrivna; Cherkashyna, L.; Чернацька, Ольга Миколаївна; Чернацкая, Ольга Николаевна; Chernatska, Olha Mykolaivna; Mazur, T.; Алексахіна, Тетяна Олексіївна; Алексахина, Татьяна Алексеевна; Aleksakhina, Tetiana Oleksiivna; Demikhov, О
    The purpose of our study was to determine the features of diabetic nephropathy, to identify the relationship between the level of albumin excretion, urine and lipid profile, genotype variants of the CYP7A1 gene in people with type 2 diabetes and diabetic nephropathy. Material and methods. Patients were divided into three groups. Normoalbinuria was detected in group I, and II - microalbuminuria, and III - macroalbuminuria. Determination of albumin to creatinine ratio was more accurate, although more expensive method. We examined single nucleotide polymorphism -204A> C [rs 3808607] of the promoter region of the CYP7A1 gene. Results. It was established that homozygotes by the major allele with genotype AA had lower values of albuminuria, atherogenic lipoproteins, total cholesterol, triglycerides and higher levels of anti- atherogenic lipoproteins than patients with AС and СС genotypes. Conclusion. The СС genotype was most unfavorable in the prognostic plan, since homozygotes for this minor allele were characterized by higher values of albuminuria, total cholesterol, triglycerides, and lower values of high-density lipoprotein.
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    The peculiarities of uricemia for patients with diabetic nephropathy and arterial hypertension
    (Sumy State University, 2017) Чернацька, Ольга Миколаївна; Чернацкая, Ольга Николаевна; Chernatska, Olha Mykolaivna; Приступа, Людмила Никодимівна; Приступа, Людмила Никодимовна; Prystupa, Liudmyla Nykodymivna
    The coexistent of type 2 diabetes mellitus (DM) and arterial hypertension (AH) is associated with increase of heart failure risk and stroke. Albuminuria is not only the indicator of diabetic nephropathy (DN), it is also the marker of cardiovascular complications for patients with type 2 DM and AH. Hyperuricemia is a confirmed independent risk factor for cardiovascular morbidity and mortality. The aim of our study was the analysis of correlation between uricemia and diabetic nephropathy markers in patients with coexistent arterial hypertension for confirmation the important role of increased uric acid levels in blood in kidney disorders progression.
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    Особливості ендотеліальної дисфункції у пацієнтів із діабетичною нефропатією та артеріальною гіпертензією
    (Сумський державний університет, 2017) Чернацька, Ольга Миколаївна; Чернацкая, Ольга Николаевна; Chernatska, Olha Mykolaivna
    Мета: дослідження взаємозв’язку між вираженістю ендотеліальної дисфункції (ЕД) та діабетичної нефропатії (ДН) у пацієнтів із цукровим діабетом (ЦД) 2-го типу та артеріальною гіпертензією (АГ).